Wnt/β-catenin通路对宫颈细胞自噬影响的研究进展

doi:10.3870/j.issn.1672-8009.2026.03.014

摘要/Abstract

摘要： 自噬在宫颈癌发展中具有双重调控作用。研究表明,Wnt/β-catenin信号通路与细胞自噬之间存在相互抑制关系:活跃的Wnt通路通过下调Beclin 1、抑制GSK-3β等方式抑制自噬;而自噬也可降解Dvl蛋白以限制Wnt通路过度激活。宫颈细胞中,该通路可通过多种途径被异常激活:如E6蛋白上调下游靶基因cyclin D1、E7蛋白解除PP2A抑制,非编码RNA circRNF121重新激活Wnt信号及非编码RNA NEAT1增加核内β-catenin的积累,进而调控宫颈细胞自噬,促进肿瘤进展。靶向该通路关键环节可为宫颈癌治疗提供新策略,未来对Wnt通路对自噬的双向调控机制的深入探索,将进一步推动精准治疗的发展。

关键词: Wnt信号通路, 宫颈癌, 高危型人乳头瘤病毒, 自噬

Abstract: Autophagy plays a dual regulatory role in the development of cervical cancer.Studies indicate a mutually inhibitory relationship between the Wnt/β-catenin signaling pathway and cellular autophagy:activated Wnt pathway suppresses autophagy by downregulating Beclin 1 and inhibiting GSK-3β,while autophagy can degrade Dvl protein to restrict excessive activation of the Wnt pathway.In cervical cells,this pathway can be aberrantly activated through various mechanisms:for example,the E6 protein upregulates the downstream target gene cyclin D1 and E7 protein to release the PP2A inhibition;the non-coding RNA circRNF121 reactivates Wnt signaling;and the non-coding RNA NEAT1 increases the nuclear β-catenin accumulation.These mechanisms subsequently modulate autophagy in cervical cells and promote tumor progression.Targeting key components of this pathway may offer new strategies for cervical cancer treatment.Future exploration of the bidirectional regulatory mechanisms of the Wnt pathway on autophagy will advance the development of precision therapy.

Key words: Wnt signaling pathway, cervical cancer, high-risk human papillomavirus, autophagy

中图分类号:

R373
R711

赵欣怡, 王志莲. Wnt/β-catenin通路对宫颈细胞自噬影响的研究进展[J]. 医学分子生物学杂志, 2026, 23(3): 337-341.

ZHAO Xinyi, WANG Zhilian. Role of Wnt/β-Catenin Pathway in Autophagy of Cervical Cells[J]. Journal of Medical Molecular Biology, 2026, 23(3): 337-341.

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