医学分子生物学杂志 ›› 2025, Vol. 22 ›› Issue (3): 266-270.doi: 10.3870/j.issn.1672-8009.2025.03.009

• 论著 • 上一篇    下一篇

MCUR1 在三阴性乳腺癌中的表达及其临床预后价值 #br#

  

  1. 武汉大学中南医院1胃肠外科,2病理科 武汉市, 430071 3肿瘤生物学行为湖北省重点实验室 & 湖北省肿瘤医学临床研究中心 武汉市, 430071
  • 出版日期:2025-05-31 发布日期:2025-06-12
  • 基金资助:
    湖北省自然科学基金 (No. 2021CFB100)

Expression and Clinical Prognostic Value of MCUR1 in Triple-negative Breast Cancer #br#

  1. 1Department of Gastrointestinal Surgery,2Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China 3Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, China
  • Online:2025-05-31 Published:2025-06-12

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摘要： 目的 探究三阴性乳腺癌 (triple-negative breast cancer, TNBC) 中线粒体钙单向转运体调节分子1 (mitochondrial calcium uniporter regulator 1, MCUR1) 的表达及其临床意义。 方法 采用免疫组织化学技术检测 MCURl 蛋白在 98 对 TNBC 组织及对应癌旁组织中的表达差异, 以及 TNBC 组织中 MCURl 表达与患者临床病理特征以及总生存期之间的关系。 结果 MCUR1 在 TNBC 中的表达高于癌旁组织 (t = 34. 58, P< 0. 01), 且 MCUR1 高表达与肿瘤组织学分级、 T 分期以及 TNM 分期均显著相关 (P 0. 05); 进一步生存分析表明, 高表达 MCUR1 患者的总体生存率低于低表达组 ( χ2 = 4. 591, P = 0. 032), 且 MCUR1 高表达是TNBC 预后不佳的独立危险因素 (HR = 2. 106, 95 % CI: 1. 013 ~ 5. 628, P = 0. 035)。 结论 MCUR1 在 TNBC 组织中表达上调, MCUR1 高表达与不良预后相关, 是评估 TNBC 患者预后的潜在生物标志物。

关键词: 三阴性乳腺癌, 线粒体钙单向转运体调节分子 1, 免疫组织化学, 临床病理特征, 预后

Abstract: Objective To analyze the expression of mitochondrial calcium uniporter regulator 1 (MCURl) in triple-negative breast cancer (TNBC) and its clinical significance. Methods  Immunohistochemistry was used to detect the expression of MCUR1 protein in TNBC tissues and corresponding adjacent tissues of 98 patients. The relationship between MCURl expression in tumor tissuesand patients’clinicopathological features and overall survival was further analyzed. Results  MCUR1was overexpressed in TNBC, and its expression level was significantly higher than that in the adjacent tissues (t = 34. 58, P < 0. 01). Clinicopathological analysis showed that high MCUR1 expression in TNBC was significantly correlated with tumor grade, T stage, and TNM stage ( P 0. 05,respectively). Further survival analysis showed that patients with high expression level of MCUR1had a lower overall survival rate than those with low expression level ( χ2 = 4. 591, P = 0. 032), which was an independent risk factor for poor prognosis of TNBC (HR = 2. 106, 95 % CI: 1. 013-5. 628, P = 0. 035). Conclusion  The expression of MCUR1 in TNBC tissues is up-regulated, andits high expression is associated with tumor progression and poor prognosis, which is a potential biomarker to evaluate the prognosis of TNBC patients.

Key words:

triple-negative breast cancer, mitochondrial calcium uniporter regulator 1, immunohistochemistry, clinicopathological features, prognosis

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