关键词: 甲状腺癌, GATA 结合蛋白 3, 临床病理特征, 手术预后

Abstract: Objective To analyze the expression of GATA binding protein 3 ( GATA3) inthyroid carcinoma and its relationship with clinicopathological features and surgical prognosis. Methods A total of 150 patients with thyroid carcinoma treated by surgery in Xilingol LeagueCentral Hospital, Inner Mongolia from August 2016 to December 2017 were selected, and the expression level of GATA3 protein was detected by immunohistochemistry between the cancer tissues and the normal tissues at the cutting edge. The expression level of GATA3 protein was compared between the cancer tissues and the normal tissues at the cutting edge, and the expression level of GATA3 protein in the thyroid carcinoma tissues of patients with different clinical and pathological characteristics was also compared. The relationship between the expression level of GATA3 protein incancer tissues and the surgical prognosis was analyzed after 5 years follow-up. Results The expression level of GATA3 protein in the thyroid carcinoma tissues was lower than that in the normal tissues (P < 0. 05). The expression level of GATA3 protein was lower in the thyroid carcinoma tissuesof undifferentiated and medullary carcinoma, TNM stage Ⅲ -Ⅳ, multiple lesions, maximum tumor diameter ≥ 2 cm, and patients with lymph node metastasis than in the thyroid carcinoma tissues of papillary adenocarcinoma and follicular adenocarcinoma, TNM stage Ⅰ -Ⅱ , single lesion, maximum tumor diameter < 2 cm, and patients without lymph node metastasis (P < 0. 05). During thefollow-up period, the survival rate of thyroid cancer patients was 83. 45 % , and the mortality ratewas 16. 55 % . Undifferentiated carcinoma ( RR = 1. 772, 95 % CI: 1. 221-2. 571 ), medullary carcinoma (RR = 2. 423, 95 % CI: 1. 609-3. 650), TNM stage Ⅲ -Ⅳ ( RR = 2. 020, 95 % CI:1. 447-2. 818), multiple lesions (RR = 1. 914, 95 % CI: 1. 421-2. 578), maximum tumor diameter ≥ 2 cm (RR = 1. 818, 95 % CI: 1. 129-2. 928), lymph node metastasis (RR = 1. 937, 95 %CI: 1. 241-3. 022), GATA3 protein expression (RR = 0. 488, 95 % CI: 0. 333-0. 715) were allfactors affecting the death of thyroid carcinoma patients ( P < 0. 05). The survival rate of patientswith high expression of GATA3 protein was higher than that of patients with low expression of GATA3 protein (P< 0. 05). Conclusion The expression of GATA3 protein is low in thyroid cancertissues, and the expression of GATA3 protein is related to pathological type, TNM stage, numberof lesions, tumor size and lymph node metastasis. The above indicators are all factors affecting theprognosis of patients after surgery.

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