衰老的序曲——肠道屏障崩塌与免疫失调

doi:10.3870/j.issn.1672-8009.2026.01.013

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (1): 90-96.doi: 10.3870/j.issn.1672-8009.2026.01.013

• “衰老与慢性疾病”专题 • 上一篇下一篇

衰老的序曲——肠道屏障崩塌与免疫失调

张静¹, 史岸冰^2,3

¹华中科技大学同济医学院附属武汉儿童医院肝胆外科武汉市,430016
²华中科技大学同济医学院基础医学院生物化学与分子生物学系武汉市,430030
³华中科技大学细胞架构研究中心武汉市,430030

收稿日期:2025-07-22 发布日期:2026-01-29
通讯作者: 史岸冰(E-mail:ashi@hust.edu.cn)
基金资助:
国家重点研发计划(No.2024YFA1802601、No.2021-YFA1300302),国家自然科学基金(No.92357302、No.32320103007、No.32130027、No.32400568)

The Prelude to Aging:The Deterioration of the Intestinal Barrier and Decline in Immune Function

ZHANG Jing¹, SHI Anbing^2,3

¹Department of Hepatobiliary Surgery,Wuhan Children’s Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430016,China
²Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China
³Cell Architecture Research Center,Huazhong University of Science and Technology,Wuhan,430030,China

Received:2025-07-22 Published:2026-01-29
Contact: SHI Anbing(E-mail:ashi@hust.edu.cn)
Supported by:
National Key R&D Program of China(No.2024YFA1802601,No.2021YFA1300302),the National Natural Science Foundation of China(No.92357302,No.32320103007,No.32130027,No.32400568)

摘要/Abstract

摘要： 肠道屏障是人体与外界环境交互的关键防线,其功能衰退是衰老过程的重要特征。随着年龄的增长,肠道屏障的结构和功能逐渐受损,表现为肠道通透性增加、免疫功能下降以及肠道微生物群失调,涉及多种生理、细胞和分子多个层面。这些变化不仅影响局部肠道健康,还可能引发全身性的炎症反应和免疫功能衰退,进而加速衰老进程。文章综述了肠道屏障衰老的特征、机制及其对全身健康的影响,并探讨了潜在的干预策略。

关键词: 肠道屏障, 衰老, 炎症性衰老, 肠漏, 微生物群

Abstract: The intestinal barrier constitutes a critical defense system that separates the human body from the external environment.Its functional impairment is a hallmark of the aging process.As individuals age,the structure and function of the intestinal barrier gradually deteriorate,manifesting as increased intestinal permeability,impaired immune function,and dysbiosis of the gut microbiota,involving complex alterations at multiple physiological,cellular,and molecular levels.Such impairments not only compromise local intestinal homeostasis but may also induce systemic inflammation and immune dysfunction,thereby contributing to the overall acceleration of aging.This article reviews the characteristics,mechanisms,and systemic health implications of intestinal barrier aging,and explores potential intervention strategies.

Key words: intestinal barrier, aging, inflammatory aging, leaky gut, microbiota

中图分类号:

张静, 史岸冰. 衰老的序曲——肠道屏障崩塌与免疫失调[J]. 医学分子生物学杂志, 2026, 23(1): 90-96.

ZHANG Jing, SHI Anbing. The Prelude to Aging:The Deterioration of the Intestinal Barrier and Decline in Immune Function[J]. Journal of Medical Molecular Biology, 2026, 23(1): 90-96.

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衰老的序曲——肠道屏障崩塌与免疫失调

The Prelude to Aging:The Deterioration of the Intestinal Barrier and Decline in Immune Function

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