急性胰腺炎患者血清circ_UTRN和circ_ZFP644表达与病情严重程度的关系

doi:10.3870/j.issn.1672-8009.2026.05.010

摘要/Abstract

摘要： 目的研究急性胰腺炎（acute pancreatitis,AP）患者血清circ_UTRN和circ_ZFP644表达与病情严重程度的关系。方法选取2020年10月~2025年8月期间收治的188例AP患者作为研究的AP组,另选90例参加体检的健康者作为对照组,检测血清circ_UTRN和circ_ZFP644的表达水平。分析AP患者血清circ_UTRN、circ_ZFP644的表达水平与AP严重程度床边指数（bedside index for severity in acute pancreatitis,BISAP）评分、急性生理学和慢性健康状况评价Ⅱ（acute physiology and chronic health evaluation Ⅱ,APACHEⅡ）评分的相关性、AP患者预后的影响因素及血清circ_UTRN与circ_ZFP644的表达水平对预后的预测能力。结果相较于对照组,AP组患者血清中circ_UTRN和circ_ZFP644的表达水平显著降低（P<0.05）;AP组内血清中circ_UTRN和circ_ZFP644的表达水平为轻症组>中重症组>重症组（P<0.05）。AP组患者血清circ_UTRN和circ_ZFP644表达水平与BISAP评分和APACHEⅡ评分呈负相关（P<0.05）;预后不良组AP患者的血清circ_UTRN和circ_ZFP644表达水平低于预后良好患者,BISAP评分、APACHEⅡ评分、C反应蛋白、降钙素原水平高于预后良好患者（P<0.05）;血清circ_UTRN和circ_ZFP644是AP预后不良的保护因素,BISAP评分、APACHEⅡ评分是AP预后不良的危险因素（P<0.05）;血清circ_UTRN和circ_ZFP644联合预测AP预后的曲线下面积高于两项指标单独预测（P<0.05）。结论血清circ_UTRN与circ_ZFP644的低表达状态与AP患者病情进展及不良预后显著相关,联合检测对AP预后具有预测价值。

关键词: 急性胰腺炎, circ_UTRN, circ_ZFP644, 预后

Abstract: Objective This study aimed to elucidate the correlation between serum levels of circ_UTRN and circ_ZFP644 and disease severity in patients with acute pancreatitis （AP）. Methods A cohort of 188 AP patients admitted between October 2020 and August 2025 was enrolled as the AP group, while 90 healthy individuals undergoing routine physical examinations served as the control group. Serum expression levels of circ_UTRN and circ_ZFP644 were quantified using quantitative real-time polymerase chain reaction. Based on clinical severity criteria, AP patients were stratified into mild, moderately severe, and severe subgroups for comparative analysis, and into good prognosis group and poor prognosis group according to the prognosis. The correlations between the expression levels of serum circ_UTRN and circ_ZFP644 in AP patients and the bedside index for severity in acute pancreatitis （BISAP） score and the acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） score, the independent factors influencing the prognosis of AP patients, the predictive capacity of serum circ_UTRN and circ_ZFP644 expression levels for prognosis were analyzed. Results The expression levels of serum circ_UTRN and circ_ZFP644 in the AP group were lower than those in the control group, with statistically significant differences （P<0.05）. The expression levels of circ_UTRN and circ_ZFP644 in the serum of the AP group were as follows： mild group > moderately severe group > severe group（P<0.05）. The expression levels of serum circ_UTRN and circ_ZFP644 in AP patients were negatively correlated with the BISAP score and the APACHE II score （P<0.05）. The expression levels of serum circ_UTRN and circ_ZFP644 in AP patients with poor prognosis were lower than those in patients with good prognosis, while the BISAP score, APACHE II score, C-reactive protein level, and procalcitonin level were higher than those in patients with good prognosis, with statistically significant differences （P<0.05）. Serum circ_UTRN and circ_ZFP644 were protective factors for a poor prognosis in AP, while the BISAP score and APACHE II score were risk factors for a poor prognosis in AP （P<0.05）. The area under the curve for the combined prediction of AP prognosis by serum circ_UTRN and circ_ZFP644 was higher than that of either indicator alone（P<0.05）. Conclusion The low expression levels of serum circ_UTRN and circ_ZFP644 are significantly associated with disease progression and poor prognosis in AP patients, the combined detection has predictive value for the prognosis of AP.

Key words: acute pancreatitis, circ_UTRN, circ_ZFP644, prognosis

中图分类号:

R657.5

胡青青, 赵敏. 急性胰腺炎患者血清circ_UTRN和circ_ZFP644表达与病情严重程度的关系[J]. 医学分子生物学杂志, 2026, 23(5): 556-562.

HU Qingqing, ZHAO Min. Relationship Between Serum circ_UTRN and circ_ZFP644 Expression and Disease Severity in Patients with Acute Pancreatitis[J]. Journal of Medical Molecular Biology, 2026, 23(5): 556-562.

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