衰老过程中的脂质组重塑研究进展

doi:10.3870/j.issn.1672-8009.2026.03.016

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (3): 349-352.doi: 10.3870/j.issn.1672-8009.2026.03.016

• “衰老与慢性疾病”专题 • 上一篇下一篇

衰老过程中的脂质组重塑研究进展

孙鹏宇^1,2, 何康敏^1,2

¹中国科学院遗传与发育生物学研究所北京市,100101
²中国科学院大学北京市,100049

收稿日期:2026-01-07 发布日期:2026-06-01
通讯作者: 何康敏(E-mail:kmhe@genetics.ac.cn)
基金资助:
国家自然科学基金项目(No.32525023、No.32321004),国家重点研发计划(No.2022YFA1304500)

Research Progress on Lipidome Remodeling During Aging

SUN Pengyu^1,2, HE Kangmin^1,2

¹Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,100101,China
²University of Chinese Academy of Sciences,Beijing,100049,China

Received:2026-01-07 Published:2026-06-01
Contact: HE Kangmin(E-mail:kmhe@genetics.ac.cn)
Supported by:
National Natural Science Foundation of China(No.32525023,No.32321004),and the National Key R&D Program of China(No.2022YFA1304500).

摘要/Abstract

摘要： 衰老是机体生理功能随时间渐进性衰退的复杂生物学过程,伴随着一系列跨周期、多层级、复杂动态的细胞和分子网络变化。脂质作为细胞膜结构、能量储存和信号传导的核心分子,在维持细胞功能和稳态中发挥着重要作用,脂质代谢失衡可能是衰老及多种人类重大疾病的重要驱动因素。近年来,随着脂质组学技术的发展,通过对多种模式动物以及人类衰老过程中的脂质组动态进行分析,逐步揭示了脂质组在衰老中呈现的共性变化规律与组织特异性重塑模式。文章结合近期基于小鼠与人类衰老研究的重要脂质组学成果,对相关进展进行简要评述,并对该领域当前面临的挑战与未来发展方向进行展望。

关键词: 衰老, 脂质组, 脂代谢重塑

Abstract: Aging is a complex biological process marked by the progressive decline of physiological functions over time,accompanied by lifespan-wide,multilevel,and dynamically evolving changes in cellular and molecular networks.Lipids,as essential molecules for cellular membrane architecture,energy storage,and signal transduction,play critical roles in maintaining cell function and homeostasis.Dysregulation of lipid metabolism may serve as an important driving force in aging and a wide range of human diseases.In recent years,advances in lipidomics technologies have enabled systematic characterization of dynamic lipidome alterations during aging in multiple model organisms as well as in humans.These studies have gradually revealed both conserved age-associated lipidomic patterns and tissue-specific remodeling features.Here,we briefly review recent lipidomics findings from mouse and human aging studies,highlight major advances in the field,and discuss current challenges and future perspectives.

Key words: aging, lipidome, lipidome remodeling

中图分类号:

孙鹏宇, 何康敏. 衰老过程中的脂质组重塑研究进展[J]. 医学分子生物学杂志, 2026, 23(3): 349-352.

SUN Pengyu, HE Kangmin. Research Progress on Lipidome Remodeling During Aging[J]. Journal of Medical Molecular Biology, 2026, 23(3): 349-352.

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衰老过程中的脂质组重塑研究进展

Research Progress on Lipidome Remodeling During Aging

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