芪地消渴胶囊联合达格列净对糖尿病肾病患者肾功能及焦亡相关因子水平的影响

doi:10.3870/j.issn.1672-8009.2026.02.006

摘要/Abstract

摘要： 目的探讨芪地消渴胶囊联合达格列净对糖尿病肾病(diabetic nephropathy,DN)患者肾功能及焦亡相关因子的影响。方法选取121例DN患者分为研究组(n=60)和对照组(n=61)。对照组予以达格列净治疗,研究组给予芪地消渴胶囊联合达格列净治疗。比较两组中医证候积分、空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、血肌酐(Scr)、24 h尿蛋白定量(24 h UP)、Nod样受体热蛋白结构域相关蛋白3(NLRP3)、胱天蛋白酶-1(Caspase-1)、白介素-18(IL-18)、白介素-1β(IL-1β)、临床疗效及不良反应。结果治疗后,研究组中医证候积分低于对照组(P<0.05)。研究组HbA1c、2hPG及FBG较对照组降低(P<0.05)。研究组eGFR较对照组增高,BUN、Scr及24 h UP较对照组降低(P<0.05)。研究组NLRP3、Caspase-1、IL-18及IL-1β低于对照组(P<0.05)。研究组临床疗效优于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P＞0.05)。结论芪地消渴胶囊联合达格列净治疗DN安全有效,可改善临床症状、血糖水平及肾功能,其机制可能与调控焦亡相关因子有关。

关键词: 芪地消渴胶囊, 糖尿病肾病, 焦亡, Nod样受体热蛋白结构域相关蛋白3, 达格列净

Abstract: Objective To evaluate the effect of Qidi Xiaoke capsule combined with dapagliflozin on renal function and pyroptosis factors levels in patients with diabetic nephropathy(DN). Methods A total of 121 DN patients were divided into study group(n=60)and control group(n=61). The control group was given dapagliflozin, and study group received Qidi Xiaoke capsule combined with dapagliflozin. The traditional Chinese medicine(TCM)syndrome score, fasting blood glucose(FPG), 2-h postprandial blood glucose(2hPG), glycated hemoglobin(HbA1c), urea nitrogen(BUN), blood creatinine(Scr), 24-h urinary protein(24 h UP), NOD-like receptor thermal protein domain associated protein 3(NLRP3), cysteine aspartate-specific proteinase-1(Caspase-1), interleukin-18(IL-18), interleukin-1β(IL-1β), clinical efficacy and adverse reactions were compared between the two groups. Results After treatment, the TCM syndrome score of study group was lower than that of control group(P<0. 05). The HbA1c, 2hPG and FBG of study group were lower than those of control group(P<0. 05). The eGFR of study group was higher than that of control group, BUN, Scr and 24 h UP were lower than in the control group(P<0. 05). The NLRP3, Caspase-1, IL-18 and IL-1β of study group were lower than control group(P<0. 05). The clinical efficacy of study group was better than that of control group(P<0. 05). There was no significance in adverse reactions between the two groups(P＞0. 05). Conclusion Qidi Xiaoke capsule combined with Dapagliflozin in the treatment of DN is safe and effective, and can improve clinical symptoms, blood glucose level and renal function, the mechanism may be related to regulation of pyroptosis factors.

Key words: Qidi Xiaoke capsule, diabetic nephropathy, pyroptosis, NOD-like receptor thermal protein domain associated protein 3, dapagliflozin

中图分类号:

R587.2

高芳, 李红, 朱剑, 齐文帅, 刘素文. 芪地消渴胶囊联合达格列净对糖尿病肾病患者肾功能及焦亡相关因子水平的影响[J]. 医学分子生物学杂志, 2026, 23(2): 150-155.

GAO Fang, LI Hong, ZHU Jian, QI Wenshuai, LIU Suwen. Effect of Qidi Xiaoke Capsule Combined with Dapagliflozin on Renal Function and Pyroptosis Factors Levels in Patients with Diabetic Nephropathy[J]. Journal of Medical Molecular Biology, 2026, 23(2): 150-155.

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