mTOR 在糖尿病血管病变中的研究进展

doi:10.3870/j.issn.1672-8009.2022.05.012

医学分子生物学杂志 ›› 2022, Vol. 19 ›› Issue (5): 421-425.doi: 10.3870/j.issn.1672-8009.2022.05.012

mTOR 在糖尿病血管病变中的研究进展

¹山西医科大学第九临床医学院内分泌科太原市, 030009 ²山西白求恩医院 (山西医学科学院、同济山西医院), 山西医科大学第三医院内分泌科太原市, 030032 ³华中科技大学同济医学院附属同济医院内分泌科武汉市, 430030 ⁴山西医科大学研究生学院太原市, 030001

出版日期:2022-09-30 发布日期:2023-01-13

Research Progress of mTOR in Diabetic Angiopathy

¹Department of Endocrinology, the Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030009, China ²Department of Endocrinology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China ³ Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China ⁴ Department of Graduate School, Shanxi Medical University, Taiyuan, 030001, China

Online:2022-09-30 Published:2023-01-13

摘要/Abstract

摘要： 糖尿病血管病变是糖尿病致残、致死的主要原因, 然而目前多种治疗策略对糖尿病血管病变的防治仍未取得理想的结果。哺乳动物雷帕霉素靶蛋白 (mechanistic target of rapamycin kinase, mTOR) 是一种存在于真核生物中的丝氨酸/ 苏氨酸蛋白激酶, 在多种生物过程中发挥着重要作用。研究发现 mTOR 可通过调节细胞增殖、凋亡、自噬、氧化应激及炎性反应等路径参与糖尿病血管病变的发生发展。文章就 mTOR 对糖尿病相关动脉粥样硬化、糖尿病肾病及糖尿病视网膜病变中的影响及相关机制进行综述, 为糖尿病血管病变的防治提供新策略。

关键词: 哺乳动物雷帕霉素靶蛋白, 糖尿病血管病变, 糖尿病相关动脉粥样硬化, 糖尿病视网膜病变, 糖尿病肾病

Abstract: Diabetic angiopathy is the main cause of disability and death in diabetes. However, strategies for the prevention and treatment of diabetic angiopathy have not achieved ideal results. Mechanistic target of rapamycin kinase ( mTOR) is a serine / threonine kinase presented in eukaryotes and plays an important role in various biological processes. A large number of studies have found that mTOR could participate in the occurrence and progress of diabetic angiopathy by regulating cell proliferation, apoptosis, autophagy, oxidative stress and inflammatory responses. This article reviews the effect and related mechanisms of mTOR on diabetic atherosclerosis, diabetic nephropathy and diabetic retinopathy, and provides a new insight for the prevention and treatment of diabetic angiopathy.

Key words: mechanistic target of rapamycin kinase, diabetic angiopathy, diabetic atherosclerosis, diabetic retinopathy, diabetic nephropathy

中图分类号:

R587. 2

魏姣姣 , 刘师伟, , 段瑞雪, , 吴亚茹 , 李楠. mTOR 在糖尿病血管病变中的研究进展[J]. 医学分子生物学杂志, 2022, 19(5): 421-425.

WEI Jiaojiao , LIU Shiwei , , DUAN Ruixue , , WU Yaru , LI Nan . Research Progress of mTOR in Diabetic Angiopathy [J]. Journal of Medical Molecular Biology, 2022, 19(5): 421-425.

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mTOR 在糖尿病血管病变中的研究进展

Research Progress of mTOR in Diabetic Angiopathy

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