糖代谢紊乱在脑小血管病中作用的研究进展*

doi:10.3870/j.issn.1672-0741.25.09.014

摘要/Abstract

摘要： 脑小血管病(cerebral small vessel disease,CSVD)是指涉及直径40～200 μm的脑小动脉、微动脉、毛细血管及微静脉的一组脑部症状和形态学改变。这种疾病多发于老年人群,对健康构成重大威胁。糖代谢紊乱是CSVD进展的关键独立危险因素,可通过胰岛素抵抗、慢性炎症反应及氧化应激等机制,诱发血管内皮功能障碍、血脑屏障破坏及脑白质损伤,加速CSVD进程。该文综述了糖代谢在CSVD中作用的研究进展,以期为CSVD的临床治疗提供理论依据,并为CSVD发病机制的探究提供线索。

关键词: 脑小血管病, 糖代谢紊乱, 白质损伤

Abstract: Cerebral small vessel disease(CSVD)refers to a group of pathological processes affecting the small cerebral arteries,arterioles,capillaries,and venules of the brain,typically 40-200 μm in diameter.This disease is common in the elderly population and poses a significant threat to their health.Disorder of glucose metabolism is a key independent risk factor for CSVD progression.It can induce vascular endothelial dysfunction,disruption of the blood-brain barrier,and white matter injury through mechanisms such as insulin resistance,chronic inflammatory responses,and oxidative stress,thereby accelerating CSVD.This article reviews research advances on the role of glucose metabolism disorder in CSVD,aiming to provide a theoretical basis for the clinical treatment of CSVD and a reference for understanding its pathogenesis.

Key words: cerebral small vessel disease, glucose metabolism disorder, white matter injury

中图分类号:

R743

李雨晴, 杨依, 弓玄伟, 于跃, 马存根, 阴俊俊, 宋丽娟. 糖代谢紊乱在脑小血管病中作用的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(2): 284-289.

Li Yuqing, Yang Yi, Gong Xuanwei et al. Research Progress on the Role of Glucose Metabolism Disorder in Cerebral Small Vessel Disease[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(2): 284-289.

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糖代谢紊乱在脑小血管病中作用的研究进展^*

Research Progress on the Role of Glucose Metabolism Disorder in Cerebral Small Vessel Disease

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