补肾滋阴固冲汤联合艾灸及耳穴压豆治疗肾阴虚型月经过多的作用机制:一项随机对照试验*

doi:10.3870/j.issn.1672-0741.25.07.023

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (1): 11-19.doi: 10.3870/j.issn.1672-0741.25.07.023

补肾滋阴固冲汤联合艾灸及耳穴压豆治疗肾阴虚型月经过多的作用机制:一项随机对照试验^*

董泳琪¹, 阮前芳¹, 黄晓桃^1,2△, 吴云霞^2,3△

¹湖北中医药大学第一临床学院, 武汉 430061
²华中科技大学同济医学院附属湖北省妇幼保健院中西医结合科, 武汉 430070
³华中科技大学同济医学院药学院生物药学系, 武汉 430030

收稿日期:2025-07-04 出版日期:2026-02-15 发布日期:2026-02-10
通讯作者: ^△E-mail:huang68xt@sina.com(黄晓桃);wuyunxia@hust.edu.cn(吴云霞)
作者简介:董泳琪,男,2000年生,硕士研究生,E-mail:1176314358@qq.com
基金资助:
^*湖北省中医药管理局中医药重点项目(No.ZY2023Z006)

Mechanism of Action of Bushen Ziyin Guchong Decoction Combined with Moxibustion and Auricular Pressure Beans in the Treatment of Metrorrhagiaof Kidney Yin Deficiency Type:A Randomized Controlled Trial

Dong Yongqi¹, Ruan Qianfang¹, Huang Xiaotao^1,2△ et al

¹The First Clinical College of Hubei University of Chinese Medicine, Wuhan 430061, China
²Department of Integrated Traditional Chinese and Western Medicine, Hubei Maternity and Child Health Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, China

Received:2025-07-04 Online:2026-02-15 Published:2026-02-10
Contact: ^△E-mail:huang68xt@sina.com(黄晓桃);wuyunxia@hust.edu.cn(吴云霞)

摘要/Abstract

摘要： 目的评估补肾滋阴固冲汤联合艾灸及耳穴压豆治疗肾阴虚型月经过多的临床疗效、安全性及作用机制。方法采用随机对照试验,将138例肾阴虚型月经过多患者分为实验组(口服补肾滋阴固冲汤+艾灸隐白穴+耳穴压豆)和对照组(口服屈螺酮炔雌醇片Ⅱ),各69例干预3个月经周期。比较两组临床疗效、性激素(FSH、LH、E₂、PRL、P、T)、血管生成因子(VEGF、ANG-1)、子宫内膜厚度及安全性指标。结果实验组总有效率显著高于对照组(95.70% vs. 84.10%,P＜0.05)。实验组在降低FSH、LH、E2、P、VEGF、ANG-1水平,改善PBAC评分[(99.44±47.20)vs.(116.55±49.98)分]、减少子宫内膜厚度[(0.51±0.24)vs.(0.64±0.26)cm]及降低中医证候积分[(10.36±3.38)vs.(12.42±1.37)分]方面均优于对照组(均P＜0.05)。实验组不良反应发生率更低(5.8% vs.17.4%,P＝0.033)。结论补肾滋阴固冲汤联合艾灸及耳穴压豆通过调节HPO轴功能、抑制病理性血管生成及修复子宫内膜结构,显著改善肾阴虚型月经过多,疗效优于单纯西药治疗,且安全性更佳。

关键词: 月经过多, 肾阴虚型, 补肾滋阴固冲汤, 艾灸, 耳穴压豆, 随机对照试验

Abstract: Objective To evaluate the clinical efficacy,safety,and mechanism of action of Bushen Ziyin Guchong decoction combined with moxibustion and auricular point pressing in the treatment of menorrhagia of kidney yin deficiency type. Methods A randomized controlled trial was conducted in which 138 menorrhagia patients of kidney yin deficiency type were enrolled.The participants were divided into an experimental group(69 cases)and a control group(69 cases),with a 3-menstrual cycle intervention.The experimental group received oral Bushen Ziyin Guchong decoction plus moxibustion at Yinbai point(SP1)and auricular point pressing.The control group was orally administered drospirenone or ethinylestradiol Table Ⅱ.Clinical efficacy,sex hormones(FSH,LH,E2,PRL,P,T),angiogenic factors(VEGF,ANG-1),endometrial thickness,and safety indicators were compared between the two groups. Results The total effective rate of the experimental group was significantly higher than that of the control group(95.70% vs.84.10%,P<0.05).The experimental group outperformed the control group in reducing the levels of FSH,LH,E2,P,VEGF,and ANG-1;improving PBAC scores(99.44±47.20 vs.116.55±49.98);decreasing endometrial thickness(0.51±0.24 vs.0.64±0.26 cm);and lowering TCM syndrome scores(10.36±3.38 vs.12.42±1.37 points)(all P<0.05).The incidence of adverse reactions was lower in the experimental group(5.8% vs.17.4%,P=0.033). Conclusion Bushen Ziyin Guchong decoction combined with moxibustion and auricular point pressing significantly improves menorrhagia of kidney-yin deficiency type by regulating hypothalamic-pituitary-ovarian(HPO)axis function,inhibiting pathological angiogenesis,and repairing the endometrial structure.Compared with single Western medicine,it has superior efficacy and better safety.

Key words: menorrhagia, kidney-yin deficiency type, Bushen Ziyin Guchong Decoction, moxibustion, auricular pressure beans, randomized controlled trial

中图分类号:

R711.51

董泳琪, 阮前芳, 黄晓桃, 吴云霞. 补肾滋阴固冲汤联合艾灸及耳穴压豆治疗肾阴虚型月经过多的作用机制:一项随机对照试验^*[J]. 华中科技大学学报（医学版）, 2026, 55(1): 11-19.

Dong Yongqi, Ruan Qianfang, Huang Xiaotao et al. Mechanism of Action of Bushen Ziyin Guchong Decoction Combined with Moxibustion and Auricular Pressure Beans in the Treatment of Metrorrhagiaof Kidney Yin Deficiency Type:A Randomized Controlled Trial[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 11-19.

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补肾滋阴固冲汤联合艾灸及耳穴压豆治疗肾阴虚型月经过多的作用机制:一项随机对照试验^*

Mechanism of Action of Bushen Ziyin Guchong Decoction Combined with Moxibustion and Auricular Pressure Beans in the Treatment of Metrorrhagiaof Kidney Yin Deficiency Type:A Randomized Controlled Trial

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