Expressions of HSP70 and NUDC in Ovarian Cancer Tissues and Their Correlation with Disease Progression

doi:10.3870/j.issn.1672-8009.2026.02.015

Abstract

Abstract: Objective To explore the expression of heat shock protein 70(HSP70)and nuclear distribution protein C(NUDC)in ovarian cancer tissues and their relationship with disease progression.Methods A total of 150 patients with ovarian cancer(observation group)and 134 patients with non-tumor gynecological diseases(control group)were selected.The expression levels of HSP70 and NUDC in ovarian tissues were detected in the two groups.The influencing factors of ovarian cancer progression were explored by univariate and multivariate logistic regression analyses.Results The expression levels of HSP70 and NUDC in ovarian tissues in the observation group were significantly higher than those in the control group(P<0.05).Logistic regression analysis suggested that the influencing factors of ovarian cancer progression were clinical staging,other organ metastasis,high expression level of HSP70,and high expression level of NUDC(P<0.05).Conclusion The expression levels of HSP70 and NUDC in ovarian cancer tissues are significantly higher than those in non-tumor ovarian tissues,and the high expression of HSP70 and NUDC are influence factors for ovarian cancer progression.

Key words: ovarian cancer, heat shock protein 70, nuclear distribution protein C, disease progression

CLC Number:

R737.31

LIU Fang, ZHANG Du, YAN Fengjie, LI Xiaohua, SUN Yaling. Expressions of HSP70 and NUDC in Ovarian Cancer Tissues and Their Correlation with Disease Progression[J]. Journal of Medical Molecular Biology, 2026, 23(2): 218-222.

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