Research Advances in tRNA-derived Small RNA in Gynecological  Diseases

doi:10.3870/j.issn.1672-8009.2026.01.011

Abstract

Abstract: tRNA-derived small RNAs(tsRNAs)are generated from the precursor tRNA or the mature tRNA through specific enzymatic cleavage reactions and exhibit a wide range of biological functions.In the field of gynecology,tsRNAs have been demonstrated to be differentially expressed in various gynecological diseases,including ovarian cancer,endometrial cancer and endometriosis,and are closely associated with disease progression and prognosis.This review aims to summarize the progresses of current researchs on tsRNAs in gynecological disorders,with the purpose of providing new insights into their molecular mechanisms and potential applications in early diagnosis and precision medicine.

Key words: tRNA-derived small RNAs, ovarian cancer, endometrial cancer, endometriosis, biomarkers

CLC Number:

R711

HE Jiabei, LIU Liling. Research Advances in tRNA-derived Small RNA in Gynecological Diseases[J]. Journal of Medical Molecular Biology, 2026, 23(1): 79-84.

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Research Advances in tRNA-derived Small RNA in Gynecological Diseases

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