Association of Serum Txnip,Nox4,ChREBP with Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus

doi:10.3870/j.issn.1672-8009.2026.02.016

Abstract

Abstract: Objective To investigate the association between serum thioredoxin interacting protein(Txnip),NADPH oxidase 4(Nox4),carbohydrate response element binding protein(ChREBP)and diabetic retinopathy(DR)in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods A total of 324 newly diagnosed T2DM patients admitted to Xi’an Trade Union Hospital from January 2022 to May 2023 were selected and divided into DR group with DR(n=106)and control group without DR(n=218)according to the results of fundus photography.Serum Txnip,Nox4 and ChREBP levels were detected.The serum Txnip,Nox4,ChREBP levels and various clinical data were compared between the two groups.Logistic regression model was used to analyze the influencing factors of DR,and receiver operating characteristic curve was used to analyze the diagnostic value of Txnip,Nox4,ChREBP for DR.Results The levels of Txnip,Nox4,ChREBP,hypertension,the levels of triglyceride,fasting insulin and HbA1c in DR group were higher than those in the control group(P<0.05).Increased serum Txnip,Nox4 and ChREBP levels were risk factors for DR of newly diagnosed T2DM patients(P<0.05).Serum Txnip,Nox4,and ChREBP levels alone and in combination had diagnostic value for T2DM patients with DR.The area under the curve was 0.804(95 %CI:0.753-0.854),0.799(95 %CI:0.744-0.855),0.781(95 %CI:0.727-0.834),0.926(95 %CI:0.898-0.954),respectively.Conclusion The increase of serum Txnip,Nox4 and ChREBP levels is associated with the occurrence of DR in newly diagnosed T2DM patients,and the three serum indexes have good diagnostic value for DR.

Key words: type 2 diabetes mellitus, diabetic retinopathy, thioredoxin interacting protein, NADPH oxidase 4, carbohydrate response element binding protein

CLC Number:

R587.2

LI Yao, SU Peihe. Association of Serum Txnip,Nox4,ChREBP with Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus[J]. Journal of Medical Molecular Biology, 2026, 23(2): 223-228.

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