Expression Levels of CTNNB1 and Grb2 in Ovarian Cancer Tissues and Their Prognostic Significance

doi:10.3870/j.issn.1672-8009.2026.02.014

Abstract

Abstract: Objective To investigate the expression levels of catenin beta 1(CTNNB1)and growth factor receptor-bound protein 2(Grb2)in ovarian cancer tissues and their prognostic significance.Methods A total of 126 patients with ovarian cancer who were treated in Cangzhou Central Hospital from January 2019 to January 2022 were selected.Samples of the cancer tissue were included in the ovarian cancer group(n= 126),and samples of adjacent tissues at least 1 cm away from the lesion margin were included in the adjacent tissue group(n= 126).The expression of CTNNB1 and Grb2 in the tissues was detected by immunohistochemistry.The relationship between the CTNNB1,Grb2 and the clinicopathological characteristics of ovarian cancer patients were analyzed by χ² test.The influencing factors of prognosis in ovarian cancer patients were analyzed by multivariate Cox regression.Results The positive rate of CTNNB1 and Grb2 in the ovarian cancer group was higher than that in the adjacent tissue group(61.90 % vs 30.95 %,65.08 % vs 33.33 %;P<0.05).The positive expression rate of CTNNB1 and Grb2 in patients with low differentiation,FIGO stage Ⅲ-Ⅳ,lymph node metastasis,and ascites was higher than that in those with moderate/high differentiation,FIGO stage Ⅰ-Ⅱ,no lymph node metastasis,and no ascites(P<0.05).The 3-year overall survival rate of patients with positive CTNNB1 and Grb2 was lower than that of those with negative CTNNB1 and Grb2(53.85 %vs 81.25 %,54.88 %vs 81.81 %,P<0.05).Multivariate analysis showed that low differentiation(HR=3.065,95 %CI:1.348-6.967),lymph node metastasis(HR=2.765,95 %CI:1.401-5.458),positive CTNNB1(HR=3.080,95 %CI:1.594-5.951),and positive Grb2(HR=3.062,95 %CI:1.536-6.104)were independent risk factors affecting the prognosis of ovarian cancer patients(P<0.05).Conclusion CTNNB1 and Grb2 are highly expressed in ovarian cancer tissues and are significantly associated with FIGO stage,differentiation degree,lymph node metastasis,and ascites.Both of them can be used as biomarkers for auxiliary assessment of patient prognosis.

Key words: catenin beta 1, growth factor receptor-bound protein 2, ovarian cancer, prognosis

CLC Number:

R737.31

GAO Wenying, LIU Shikai, YAO Hairong. Expression Levels of CTNNB1 and Grb2 in Ovarian Cancer Tissues and Their Prognostic Significance[J]. Journal of Medical Molecular Biology, 2026, 23(2): 212-217.

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