MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制

doi:10.3870/j.issn.1672-8009.2026.01.010

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (1): 74-78.doi: 10.3870/j.issn.1672-8009.2026.01.010

MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制

郝梓淇, 冯文莉, 张静, 赵冰倩

山西医科大学第二临床医学院皮肤性病科太原市,030001

收稿日期:2025-08-11 发布日期:2026-01-29
通讯作者: 冯文莉(E-mail:Fwl92@hotmail.com)
基金资助:
山西省自然科学基金面上项目(No.202403021221324),山西省基础研究计划项目(No.202403021211116),山西省中医药管理局科研课题(No.ZYYA20102023)

The Bidirectional Regulatory Mechanism of MAPK Signaling Pathway in Drug Tolerance and Host Interaction of Candida albicans

HAO Ziqi, FENG Wenli, ZHANG Jing, ZHAO Bingqian

Department of Dermatology and Venereal Disease,The Second Hospital of Shanxi Medical University,Taiyuan,030001,China

Received:2025-08-11 Published:2026-01-29
Contact: FENG Wenli(E-mail:Fwl92@hotmail.com)
Supported by:
Natural Science Foundation of Shanxi Province(No.202403021221324),Basic Research Plan Project of Shanxi Province(No.202403021211116),Scientific Research Project of Shanxi Provincial Administration of Traditional Chinese Medicine(No.ZYYA20102023)

摘要/Abstract

摘要： 白念珠菌是人类常见的条件致病真菌,其引起的侵袭性感染死亡率高,临床防治面临严峻挑战。日益严重的耐药问题是治疗失败的主要原因之一,因此,揭示其耐药机制并寻找新的药物靶点迫在眉睫。文章围绕MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制进行综述:一方面,揭示MAPK信号通路如何介导白念珠菌与宿主的相互作用,如免疫逃逸、炎症反应等方式;另一方面,揭示MAPK信号通路介导的白念珠菌耐药机制,如细胞壁合成与重塑、菌丝形成、氧化应激以及生物膜形成等机制,及其用药研究进展,旨在为深入理解白念珠菌的致病性与耐药性提供新的视角,并为针对MAPK通路开发新型抗真菌策略提供理论依据。

关键词: 白念珠菌, MAPK信号通路, 致病机制, 耐药性

Abstract: Candida albicans is a common opportunistic pathogen fungus in humans.The invasive infection it causes have a high mortality rate,posing significant challenges for clinical prevention and treatment.The graving problem of drug resistance is one of the primary causes for treatment failure,making it urgent to elucidate its drug resistance mechanisms and identify new drug targets.This article reviews the bidirectional regulatory mechanism of the MAPK signaling pathway in Candida albicans drug tolerance and host interaction:On one hand,it reveals how the MAPK signaling pathway mediates interactions between Candida albicans and its host,such as through immune evasion and inflammatory responses;On the other hand,it elucidates the MAPK-mediated resistance mechanisms in Candida albicans,including cell wall synthesis and remodeling,hyphal formation,oxidative stress,and biofilm formation,along with recent advances in drug research.This aims to provide new insights into understanding the pathogenicity and resistance of Candida albicans and to offer theoretical support for developing novel antifungal strategies targeting the MAPK pathway.

Key words: Candida albicans, MAPK signaling pathway, pathogenesis, drug resistance

中图分类号:

R379.4

郝梓淇, 冯文莉, 张静, 赵冰倩. MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制[J]. 医学分子生物学杂志, 2026, 23(1): 74-78.

HAO Ziqi, FENG Wenli, ZHANG Jing, ZHAO Bingqian. The Bidirectional Regulatory Mechanism of MAPK Signaling Pathway in Drug Tolerance and Host Interaction of Candida albicans[J]. Journal of Medical Molecular Biology, 2026, 23(1): 74-78.

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MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制

The Bidirectional Regulatory Mechanism of MAPK Signaling Pathway in Drug Tolerance and Host Interaction of Candida albicans

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