circRNAs 在肿瘤糖酵解发生发展中作用机制研究进展

doi:10.3870/j.issn.1672-8009.2023.03.015

医学分子生物学杂志 ›› 2023, Vol. 20 ›› Issue (3): 272-278.doi: 10.3870/j.issn.1672-8009.2023.03.015

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circRNAs 在肿瘤糖酵解发生发展中作用机制研究进展

宁波大学附属人民医院呼吸与危重症医学科浙江省宁波市, 315040

出版日期:2023-05-31 发布日期:2023-05-30

Research Progress on Mechanism of circRNAs in the Occurrence and Development of Tumor Glycolysis

Department of Respiratory Disease, the Affiliated People’ s Hospital, Ningbo University, Ningbo, Zhejiang, 315040, China

Online:2023-05-31 Published:2023-05-30

摘要/Abstract

摘要： 近年来, 环状 RNA 在肿瘤治疗中的作用成为了研究热点。糖酵解是肿瘤代谢中的一个重要环节, 许多异常表达的环状 RNA 与肿瘤糖酵解过程中重要的酶类、细胞因子及信号通路都有密切的联系, 它可通过结合 microRNA 抑制其功能, 直接或间接影响下游靶蛋白的表达, 达到促进或抑制肿瘤糖酵解过程, 还可影响肿瘤患者对化疗药物产生的耐药性。文章综述了环状 RNA 通过葡萄糖转运蛋白及代谢酶、相关癌基因及转录因子、癌症相关信号通路影响肿瘤糖酵解, 以及其在肿瘤治疗和耐药等方面的研究进展。

关键词: 癌症, 环状 RNA, 糖酵解, 耐药性

Abstract: In recent years, the role of circular RNA in tumor therapy has become a research hotspot. Glycolysis is an important part of tumor metabolism. Many abnormally expressed circular RNAs are closely related to the important enzymes, cytokines and signal pathways in the process of tumor glycolysis. Binding with miRNA could inhibit the function of circular RNA, thus directly or indirectly affect the expression of downstream target proteins, promote or inhibit the process of tumor glycolysis, and also affect the resistance to chemotherapy drugs in cancer patients. This review will make a summary on circular RNA in affecting tumor glycolysis through glucose transporters and metabolic enzymes, related oncogenes and transcription factors, and cancer-related signaling pathways, and the application of circular RNA in tumor therapy and drug resistance.

Key words: cancer, circular RNA, glycolysis, drug resistance

中图分类号:

李佳维, 俞万钧, 吕佳佩, 徐涛. circRNAs 在肿瘤糖酵解发生发展中作用机制研究进展[J]. 医学分子生物学杂志, 2023, 20(3): 272-278.

LI Jiawei, YU Wanjun, LV Jiapei, XU Tao. Research Progress on Mechanism of circRNAs in the Occurrence and Development of Tumor Glycolysis[J]. Journal of Medical Molecular Biology, 2023, 20(3): 272-278.

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circRNAs 在肿瘤糖酵解发生发展中作用机制研究进展

Research Progress on Mechanism of circRNAs in the Occurrence and Development of Tumor Glycolysis

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