蒙药吉祥安坤丸对卵巢早衰模型大鼠卵巢功能的保护作用及机制研究

doi:10.3870/j.issn.1672-8009.2026.04.013

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (4): 458-465.doi: 10.3870/j.issn.1672-8009.2026.04.013

蒙药吉祥安坤丸对卵巢早衰模型大鼠卵巢功能的保护作用及机制研究

齐文斐¹, 白玉兰², 戴亮亮¹, 包国平¹, 王俊辉¹, 朝鲁门³

¹内蒙古医科大学蒙医药学院呼和浩特市,010110
²呼和浩特市中医蒙医医院蒙医妇科呼和浩特市,010020
³包头市蒙医中医医院蒙医针灸推拿(药浴)科内蒙古包头市,014040

收稿日期:2026-03-11 发布日期:2026-09-28
通讯作者: 朝鲁门(E-mail:13314891839@163.com)
基金资助:
呼和浩特市科技计划项目(No.2023-社-23)

Protective Effect and Mechanism of Mongolian Medicine Jixiang Ankun Pill on Ovarian Function in Rats with Premature Ovarian Failure

QI Wenfei¹, BAI Yulan², DAI Liangliang¹, BAO Guoping¹, WANG Junhui¹, CHAO Lumen³

¹College of Mongolian Medicine,Inner Mongolia Medical University,Hohhot,010110,China
²Department of Mongolian Medicine Gynecology,Hohhot Hospital of Traditional Chinese and Mongolian Medicine,Hohhot,010020,China
³Department of Mongolian Medicine Acupuncture Massage(Medicinal Bath),Baotou Hospital of Mongolian and Traditional Chinese Medicine,Baotou,014040,China

Received:2026-03-11 Published:2026-09-28
Contact: CHAO Lumen(E-mail:13314891839@163.com)
Supported by:
Hohhot Science and Technology Program Project (No. 2023-She-23)

摘要/Abstract

摘要： 目的研究蒙药吉祥安坤丸对卵巢早衰(premature ovarian failure,POF)大鼠的疗效及作用机制。方法 54只SD雌性大鼠随机分6组,除正常组外,其余用雷公藤多苷片建立POF模型,后各给药组灌胃相应药物36天。检测血清性激素、炎性因子、氧化应激指标,观察卵巢病理形态,检测PI3K/AKT/mTOR通路相关分子表达。结果模型组性激素紊乱、炎性及氧化应激水平异常,卵巢结构损伤严重,PI3K/AKT/mTOR通路相关分子表达异常;蒙药各浓度组及西药组均有改善,高浓度组与西药组效果最显著,可调控PI3K/AKT/mTOR通路相关分子表达。结论蒙药吉祥安坤丸可改善POF大鼠卵巢功能,机制可能与调控PI3K/AKT/mTOR通路及mTOR蛋白磷酸化有关。

关键词: 蒙药吉祥安坤丸, 卵巢早衰, SD大鼠, 性激素, 卵巢功能

Abstract: Objective To investigate the therapeutic effect of Mongolian medicine Jixiang Ankun Pill on premature ovarian failure(POF)in rats and explore its potential mechanism. Methods A total of 54 SD female rats were randomly divided into six groups.Except for the control group,the remaining groups were induced to develop a POF model using Tripterygium glycoside tablets.Subsequently,each treatment group was administered the corresponding drug via oral gavage for 36 days.Serum hormone levels,inflammatory factors,and oxidative stress markers were measured;ovarian histopathology was examined;and the expression of molecules related to the PI3K/AKT/mTOR pathway was assessed. Results The model group exhibited hormonal imbalances,abnormal levels of inflammation and oxidative stress,severe damage to ovarian structure,and abnormal expression of PI3K/AKT/mTOR pathway-related molecules.Improvements were observed in all Mongolian medicine concentration groups and the Western medicine group,with the highest concentration group and the Western medicine group showing the most significant effects. Conclusion Jixiang Ankun Pill can effectively improve ovarian function in POF rats via regulating hormone levels,inhibiting inflammation and oxidative stress,and its mechanism is closely related to the regulation of the PI3K/AKT/mTOR signaling pathway and mTOR phosphorylation.

Key words: mongolian medicine Jixiang Ankun Pills, premature ovarian failure, SD rats, sex hormone, ovarian function

中图分类号:

齐文斐, 白玉兰, 戴亮亮, 包国平, 王俊辉, 朝鲁门. 蒙药吉祥安坤丸对卵巢早衰模型大鼠卵巢功能的保护作用及机制研究[J]. 医学分子生物学杂志, 2026, 23(4): 458-465.

QI Wenfei, BAI Yulan, DAI Liangliang, BAO Guoping, WANG Junhui, CHAO Lumen. Protective Effect and Mechanism of Mongolian Medicine Jixiang Ankun Pill on Ovarian Function in Rats with Premature Ovarian Failure[J]. Journal of Medical Molecular Biology, 2026, 23(4): 458-465.

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蒙药吉祥安坤丸对卵巢早衰模型大鼠卵巢功能的保护作用及机制研究

Protective Effect and Mechanism of Mongolian Medicine Jixiang Ankun Pill on Ovarian Function in Rats with Premature Ovarian Failure

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