血清Txnip、Nox4、ChREBP与新诊断2型糖尿病患者视网膜病变的相关性

doi:10.3870/j.issn.1672-8009.2026.02.016

摘要/Abstract

摘要： 目的研究血清硫氧还蛋白相互作用蛋白(thioredoxin interacting protein,Txnip)、NADPH氧化酶4(NADPH oxidase 4,Nox4)、碳水化合物反应元件结合蛋白(carbohydrate response element binding protein,ChREBP)与新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者糖尿病视网膜病变(diabetic retinopathy,DR)的相关性。方法选择2022年1月~2023年5月西安工会医院内分泌科收治的新诊断T2DM患者324例,根据眼底照相检查结果分为存在DR的DR组(n=106)和无DR的对照组(n=218)。检测血清Txnip、Nox4、ChREBP水平。比较两组间血清Txnip、Nox4、ChREBP水平及各项临床资料的差异,采用logistic回归模型分析DR的影响因素,采用受试者工作特征曲线分析Txnip、Nox4、ChREBP对DR的诊断价值。结果 DR组血清Txnip、Nox4、ChREBP水平、高血压比例、甘油三酯、空腹胰岛素、HbA1c水平高于对照组,差异有统计学意义(P<0.05);血清Txnip、Nox4、ChREBP水平增加是新诊断T2DM患者发生DR的危险因素(P<0.05);血清Txnip、Nox4、ChREBP水平单独及联合均对T2DM患者DR具有诊断价值,曲线下面积分别为0.804(95 %CI:0.753~0.854)、0.799(95 %CI:0.744~0.855)、0.781(95 %CI:0.727~0.834)、0.926(95 %CI:0.898~0.954)。结论血清Txnip、Nox4、ChREBP水平增加与新诊断T2DM患者发生DR相关,三项血清指标对DR具有较好的诊断价值。

关键词: 2型糖尿病, 糖尿病视网膜病变, 硫氧还蛋白相互作用蛋白, NADPH氧化酶4, 碳水化合物反应元件结合蛋白

Abstract: Objective To investigate the association between serum thioredoxin interacting protein(Txnip),NADPH oxidase 4(Nox4),carbohydrate response element binding protein(ChREBP)and diabetic retinopathy(DR)in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods A total of 324 newly diagnosed T2DM patients admitted to Xi’an Trade Union Hospital from January 2022 to May 2023 were selected and divided into DR group with DR(n=106)and control group without DR(n=218)according to the results of fundus photography.Serum Txnip,Nox4 and ChREBP levels were detected.The serum Txnip,Nox4,ChREBP levels and various clinical data were compared between the two groups.Logistic regression model was used to analyze the influencing factors of DR,and receiver operating characteristic curve was used to analyze the diagnostic value of Txnip,Nox4,ChREBP for DR.Results The levels of Txnip,Nox4,ChREBP,hypertension,the levels of triglyceride,fasting insulin and HbA1c in DR group were higher than those in the control group(P<0.05).Increased serum Txnip,Nox4 and ChREBP levels were risk factors for DR of newly diagnosed T2DM patients(P<0.05).Serum Txnip,Nox4,and ChREBP levels alone and in combination had diagnostic value for T2DM patients with DR.The area under the curve was 0.804(95 %CI:0.753-0.854),0.799(95 %CI:0.744-0.855),0.781(95 %CI:0.727-0.834),0.926(95 %CI:0.898-0.954),respectively.Conclusion The increase of serum Txnip,Nox4 and ChREBP levels is associated with the occurrence of DR in newly diagnosed T2DM patients,and the three serum indexes have good diagnostic value for DR.

Key words: type 2 diabetes mellitus, diabetic retinopathy, thioredoxin interacting protein, NADPH oxidase 4, carbohydrate response element binding protein

中图分类号:

R587.2

李瑶, 苏佩合. 血清Txnip、Nox4、ChREBP与新诊断2型糖尿病患者视网膜病变的相关性[J]. 医学分子生物学杂志, 2026, 23(2): 223-228.

LI Yao, SU Peihe. Association of Serum Txnip,Nox4,ChREBP with Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus[J]. Journal of Medical Molecular Biology, 2026, 23(2): 223-228.

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