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Abstract: Acute myeloid leukemia ( AML ) is a highly aggressive hematologicalmalignancy. Currently, chemotherapy and hematopoietic stem cell transplantation remain the primary treatment options for AML, yet approximately 30 % of patients experience relapse and have a poor prognosis. Pimozide, an antipsychotic drug, is primarily used in the treatment of schizophrenia, bipolar disorder, and other conditions. Several studies have now confirmed its antitumor effects. This article aims to review the mechanisms of pimozide in AML by literature analyzing, which provides insights into treatment strategies for AML.

Key words: acute myeloid leukemia, pimozide