卵巢癌组织中HSP70、NUDC与疾病进展的相关性研究

doi:10.3870/j.issn.1672-8009.2026.02.015

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (2): 218-222.doi: 10.3870/j.issn.1672-8009.2026.02.015

卵巢癌组织中HSP70、NUDC与疾病进展的相关性研究

刘芳¹, 张都¹, 闫凤洁¹, 李小华², 孙亚玲¹

唐山市妇幼保健院¹妇科,²病理科河北省唐山市,063000

收稿日期:2025-09-01 出版日期:2026-03-31 发布日期:2026-04-03
通讯作者: 孙亚玲(E-mail:sunyaling1234@163.com)
基金资助:
河北省卫生健康委科研基金项目(No.20201482)

Expressions of HSP70 and NUDC in Ovarian Cancer Tissues and Their Correlation with Disease Progression

LIU Fang¹, ZHANG Du¹, YAN Fengjie¹, LI Xiaohua², SUN Yaling¹

¹Department of Gynecology,²Department of Pathology,Tangshan Maternal and Child Health Hospital,Tangshan,Hebei,063000,China

Received:2025-09-01 Online:2026-03-31 Published:2026-04-03
Contact: SUN Yaling(E-mail:sunyaling1234@163.com)
Supported by:
Research Project of Health Commission of Hebei Province(No.20201482)

摘要/Abstract

摘要： 目的探究卵巢癌组织中热休克蛋白70(heat shock protein 70,HSP70)、核分布蛋白C(nuclear distribution protein C,NUDC)与疾病进展的关系。方法选取150例卵巢癌患者(观察组)和134例非肿瘤妇科疾病患者(对照组),检测2组卵巢组织中HSP70与NUDC的表达情况;通过单因素及多因素Logistic回归分析卵巢癌疾病进展的影响因素。结果观察组卵巢组织中HSP70与NUDC的表达水平显著高于对照组(P<0.05);Logistic回归分析显示,卵巢癌疾病进展的影响因素有临床分期、有其他器官转移、HSP70高表达、NUDC高表达(P<0.05)。结论卵巢癌组织中HSP70与NUDC的表达水平显著高于非肿瘤卵巢组织,HSP70、NUDC高表达均为卵巢癌疾病进展的影响因素。

关键词: 卵巢癌, 热休克蛋白70, 核分布蛋白C, 疾病进展

Abstract: Objective To explore the expression of heat shock protein 70(HSP70)and nuclear distribution protein C(NUDC)in ovarian cancer tissues and their relationship with disease progression.Methods A total of 150 patients with ovarian cancer(observation group)and 134 patients with non-tumor gynecological diseases(control group)were selected.The expression levels of HSP70 and NUDC in ovarian tissues were detected in the two groups.The influencing factors of ovarian cancer progression were explored by univariate and multivariate logistic regression analyses.Results The expression levels of HSP70 and NUDC in ovarian tissues in the observation group were significantly higher than those in the control group(P<0.05).Logistic regression analysis suggested that the influencing factors of ovarian cancer progression were clinical staging,other organ metastasis,high expression level of HSP70,and high expression level of NUDC(P<0.05).Conclusion The expression levels of HSP70 and NUDC in ovarian cancer tissues are significantly higher than those in non-tumor ovarian tissues,and the high expression of HSP70 and NUDC are influence factors for ovarian cancer progression.

Key words: ovarian cancer, heat shock protein 70, nuclear distribution protein C, disease progression

中图分类号:

R737.31

刘芳, 张都, 闫凤洁, 李小华, 孙亚玲. 卵巢癌组织中HSP70、NUDC与疾病进展的相关性研究[J]. 医学分子生物学杂志, 2026, 23(2): 218-222.

LIU Fang, ZHANG Du, YAN Fengjie, LI Xiaohua, SUN Yaling. Expressions of HSP70 and NUDC in Ovarian Cancer Tissues and Their Correlation with Disease Progression[J]. Journal of Medical Molecular Biology, 2026, 23(2): 218-222.

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卵巢癌组织中HSP70、NUDC与疾病进展的相关性研究

Expressions of HSP70 and NUDC in Ovarian Cancer Tissues and Their Correlation with Disease Progression

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