赖氨酸巴豆酰化修饰的病理生理学功能及分子机制的研究进展

doi:10.3870/j.issn.1672-8009.2026.05.012

医学分子生物学杂志 ›› 2026, Vol. 23 ›› Issue (5): 571-576.doi: 10.3870/j.issn.1672-8009.2026.05.012

赖氨酸巴豆酰化修饰的病理生理学功能及分子机制的研究进展

阿合拉·哈力别克^1,2#, 王玥^1#, 曹丁戈¹, 司文喆^1,3

¹北京大学第三医院检验科北京市, 100191;
²北京协和医学院基础学院生物化学与分子生物学系北京市, 100730;
³北京大学国家卫生健康委员会心血管分子生物学与调节肽重点实验室, 血管稳态与重构全国重点实验室北京市, 100191

收稿日期:2026-03-16 出版日期:2026-09-30 发布日期:2026-09-30
通讯作者: 司文喆（E-mail：wenzhesi@bjmu.edu.cn）
作者简介:#:共同第一作者
基金资助:
北京市科技新星计划交叉合作课题（No.20260484442）,北京市自然科学基金（No.7232206）,北京大学第三医院临床重点项目创新项目A类（No.BYSYZD2024011）,北京大学第三医院交叉联合专项（No.BYSYJC2025060、No.BYSYJC2025018）

Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification

Ahela Halibieke^1,2#, WANG Yue^1#, CAO Dingge¹, SI Wenzhe^1,3

¹Department of Clinical Laboratory, Peking University Third Hospital, Beijing, 100191, China;
²Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking Union Medical College, Beijing, 100730, China;
³NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China

Received:2026-03-16 Online:2026-09-30 Published:2026-09-30
Contact: SI Wenzhe （E-mail：wenzhesi@bjmu.edu.cn）
About author:#:These authors contributed equally as first author.
Supported by:
Beijing Nova Program（No.20260484442）, Beijing Natural Science Foundation（No.7232206）, Peking University Third Hospital Clinical Key Project Innovation A（No.BYSYZD2024011）, Peking University Third Hospital Cross-Disciplinary Joint Special Fund（No.BYSYJC2025060,No.BYSYJC2025018）.

摘要/Abstract

摘要： 翻译后修饰作为功能蛋白质组学研究中的关键调控机制,广泛参与调节蛋白质活性、亚细胞定位及相互作用。其中,赖氨酸巴豆酰化是近年来发现的一种新型修饰形式,存在于组蛋白和非组蛋白中,参与基因转录、细胞周期进程和DNA损伤应答等关键生物学过程。文章围绕赖氨酸巴豆酰化在心血管系统疾病、呼吸系统疾病、神经系统疾病、肾脏疾病、糖尿病、自身免疫性疾病及生殖内分泌相关疾病中的调控作用与分子机制展开系统综述,旨在为相关疾病的靶向治疗策略提供新的理论依据和研究思路。

关键词: 巴豆酰化修饰, 分子机制, 心血管系统疾病, 呼吸系统疾病, 神经系统疾病

Abstract: Post-translational modifications serve as key regulatory mechanisms in functional proteomics, extensively involved in modulating protein activity, subcellular localization, and interactions. Among these, lysine crotonylation is a novel form of modification discovered in recent years, occurring on both histones and non-histone proteins. It participates in critical biological processes such as gene transcription, cell cycle progression, and DNA damage response. This review systematically summarizes the regulatory roles and molecular mechanisms of lysine crotonylation in cardiovascular diseases, respiratory diseases, neurological disorders, as well as kidney diseases, diabetes, autoimmune diseases, and reproductive endocrine-related conditions, aiming to provide a new theoretical foundation and research perspectives for targeted therapeutic strategies of related diseases.

Key words: crotonylation, molecular mechanism, cardiovascular disease, respiratory disease, neurological disease

中图分类号:

R363

阿合拉·哈力别克, 王玥, 曹丁戈, 司文喆. 赖氨酸巴豆酰化修饰的病理生理学功能及分子机制的研究进展[J]. 医学分子生物学杂志, 2026, 23(5): 571-576.

Ahela Halibieke, WANG Yue, CAO Dingge, SI Wenzhe. Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification[J]. Journal of Medical Molecular Biology, 2026, 23(5): 571-576.

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赖氨酸巴豆酰化修饰的病理生理学功能及分子机制的研究进展

Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification

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