炎性衰老在再生障碍性贫血中的研究进展*

doi:10.3870/j.issn.1672-0741.25.08.032

摘要/Abstract

摘要： 随着全球人口老龄化进程加速,与年龄相关的血液系统疾病负担日益加重。炎性衰老即伴随衰老出现的慢性、系统性、低度炎症状态,已被证实与心脑血管疾病、神经退行性病变等多种老年性疾病相关,但其在再生障碍性贫血(aplastic anemia,AA)这一骨髓衰竭性疾病中的具体作用机制尚未得到系统阐明。该文从炎性衰老及其发生机制、炎性衰老与再生障碍性贫血等方面展开综述,旨在揭示AA通过“骨髓微环境-造血干细胞-免疫系统”三重网络协同驱动AA患者炎性衰老的机制,为未来AA的防治策略提供借鉴和参考。

关键词: 炎性衰老, 再生障碍性贫血, 骨髓衰竭

Abstract: As the global population ages at an accelerating pace,the burden of age-related hematological diseases is increasing.Inflammaging,a chronic,systemic,low-grade inflammatory state associated with aging,has been linked to various age-related diseases,including cardiovascular,cerebrovascular,and neurodegenerative disorders.However,its specific mechanistic role in aplastic anemia(AA)—a bone marrow failure—remains systematically unelucidated.This review comprehensively summarizes inflammaging and its underlying mechanisms,with a particular focus on its role in AA.We aim to elucidate how AA contributes to inflammaging in patients through a bone marrow microenvironment-hematopoietic stem cells-immune system triad network,thereby providing a rationale for future AA prevention and treatment.

Key words: inflammaging, aplastic anemia, bone marrow failure

中图分类号:

R556.5

陈珂, 杨向东, 杨倩倩, 邱钰, 赵子沛, 李国庆, 曹雨潇, 刘彩霞. 炎性衰老在再生障碍性贫血中的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(2): 302-307.

Chen Ke, Yang Xiangdong , Yang Qianqian et al. Research Progress on Inflammaging in Aplastic Anemia[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(2): 302-307.

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炎性衰老在再生障碍性贫血中的研究进展^*

Research Progress on Inflammaging in Aplastic Anemia

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