Protective Effect and Mechanism of Mongolian Medicine Jixiang Ankun Pill on Ovarian Function in Rats with Premature Ovarian Failure

doi:10.3870/j.issn.1672-8009.2026.04.013

Abstract

Abstract: Objective To investigate the therapeutic effect of Mongolian medicine Jixiang Ankun Pill on premature ovarian failure(POF)in rats and explore its potential mechanism. Methods A total of 54 SD female rats were randomly divided into six groups.Except for the control group,the remaining groups were induced to develop a POF model using Tripterygium glycoside tablets.Subsequently,each treatment group was administered the corresponding drug via oral gavage for 36 days.Serum hormone levels,inflammatory factors,and oxidative stress markers were measured;ovarian histopathology was examined;and the expression of molecules related to the PI3K/AKT/mTOR pathway was assessed. Results The model group exhibited hormonal imbalances,abnormal levels of inflammation and oxidative stress,severe damage to ovarian structure,and abnormal expression of PI3K/AKT/mTOR pathway-related molecules.Improvements were observed in all Mongolian medicine concentration groups and the Western medicine group,with the highest concentration group and the Western medicine group showing the most significant effects. Conclusion Jixiang Ankun Pill can effectively improve ovarian function in POF rats via regulating hormone levels,inhibiting inflammation and oxidative stress,and its mechanism is closely related to the regulation of the PI3K/AKT/mTOR signaling pathway and mTOR phosphorylation.

Key words: mongolian medicine Jixiang Ankun Pills, premature ovarian failure, SD rats, sex hormone, ovarian function

CLC Number:

QI Wenfei, BAI Yulan, DAI Liangliang, BAO Guoping, WANG Junhui, CHAO Lumen. Protective Effect and Mechanism of Mongolian Medicine Jixiang Ankun Pill on Ovarian Function in Rats with Premature Ovarian Failure[J]. Journal of Medical Molecular Biology, 2026, 23(4): 458-465.

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