Therapeutic Effect and Mechanism of Ropivacaine in Mice Model of Allergic Rhinitis

doi:10.3870/j.issn.1672-8009.2026.04.012

Abstract

Abstract: Objective To explore the effect of ropivacaine on alleviating ovalbumin(OVA)-induced allergic rhinitis(AR)in mice. Methods Mice were randomly divided into 5 groups:control group,AR group,low-dose Ropivacaine group(1 mg/kg),high-dose Ropivacaine group(5 mg/kg)and Dexamethasone(Dex)positive group(2 mg/kg),with 5 mice in each group.Indicator evaluations were conducted after the last drug administration. Results The body weight of mice in the high-dose Ropivacaine group and Dex group was greater than that in the AR group(P<0.05),and the relative spleen weight,the times of nose rubbing,sneezing and runny nose,levels of serum histamine,OVA-specific immunoglobulin E(IgE),total IgE,total IgG1 and β-hexosaminidase,levels of iIL-1β,IL-6,TNF-α,IL-4 and IL-5 in nasal lavage fluid and the protein expression levels of p65 and p-IkBα in the nasal mucosa were lower than those in the AR group(P<0.05).Eosinophil infiltration was reduced. Conclusion High-dose ropivacaine can relieve OVA-induced rhinitis symptoms and inflammatory infiltration of nasal mucosa of mice with AR.The mechanism may be related to the inhibition of NF-κB signaling pathway.

Key words: ropivacaine, ovalbumin, allergic rhinitis, cytokines, NF-κB signaling pathway

CLC Number:

R962.1

WANG Huan, ZHANG He, YIN Meng, ZHANG Huinan, LIU Guang, GUO Jifeng. Therapeutic Effect and Mechanism of Ropivacaine in Mice Model of Allergic Rhinitis[J]. Journal of Medical Molecular Biology, 2026, 23(4): 452-457.

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