Research Progress on Lipidome Remodeling During Aging

doi:10.3870/j.issn.1672-8009.2026.03.016

Journal of Medical Molecular Biology ›› 2026, Vol. 23 ›› Issue (3): 349-352.doi: 10.3870/j.issn.1672-8009.2026.03.016

• Special Topic on Aging and Chronic Disease • Previous Articles Next Articles

Research Progress on Lipidome Remodeling During Aging

SUN Pengyu^1,2, HE Kangmin^1,2

¹Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,100101,China
²University of Chinese Academy of Sciences,Beijing,100049,China

Received:2026-01-07 Published:2026-06-01
Contact: HE Kangmin(E-mail:kmhe@genetics.ac.cn)
Supported by:
National Natural Science Foundation of China(No.32525023,No.32321004),and the National Key R&D Program of China(No.2022YFA1304500).

Abstract

Abstract: Aging is a complex biological process marked by the progressive decline of physiological functions over time,accompanied by lifespan-wide,multilevel,and dynamically evolving changes in cellular and molecular networks.Lipids,as essential molecules for cellular membrane architecture,energy storage,and signal transduction,play critical roles in maintaining cell function and homeostasis.Dysregulation of lipid metabolism may serve as an important driving force in aging and a wide range of human diseases.In recent years,advances in lipidomics technologies have enabled systematic characterization of dynamic lipidome alterations during aging in multiple model organisms as well as in humans.These studies have gradually revealed both conserved age-associated lipidomic patterns and tissue-specific remodeling features.Here,we briefly review recent lipidomics findings from mouse and human aging studies,highlight major advances in the field,and discuss current challenges and future perspectives.

Key words: aging, lipidome, lipidome remodeling

CLC Number:

SUN Pengyu, HE Kangmin. Research Progress on Lipidome Remodeling During Aging[J]. Journal of Medical Molecular Biology, 2026, 23(3): 349-352.

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Research Progress on Lipidome Remodeling During Aging

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