The Prelude to Aging:The Deterioration of the Intestinal Barrier and Decline in Immune Function

doi:10.3870/j.issn.1672-8009.2026.01.013

Abstract

Abstract: The intestinal barrier constitutes a critical defense system that separates the human body from the external environment.Its functional impairment is a hallmark of the aging process.As individuals age,the structure and function of the intestinal barrier gradually deteriorate,manifesting as increased intestinal permeability,impaired immune function,and dysbiosis of the gut microbiota,involving complex alterations at multiple physiological,cellular,and molecular levels.Such impairments not only compromise local intestinal homeostasis but may also induce systemic inflammation and immune dysfunction,thereby contributing to the overall acceleration of aging.This article reviews the characteristics,mechanisms,and systemic health implications of intestinal barrier aging,and explores potential intervention strategies.

Key words: intestinal barrier, aging, inflammatory aging, leaky gut, microbiota

CLC Number:

ZHANG Jing, SHI Anbing. The Prelude to Aging:The Deterioration of the Intestinal Barrier and Decline in Immune Function[J]. Journal of Medical Molecular Biology, 2026, 23(1): 90-96.

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