[1] COWAN A J,GREEN D J,KWOK M,et al.Diagnosis and management of multiple myeloma:A review[J].JAMA,2022,327(5):464-477. [2] RAJKUMAR S V.Multiple myeloma:2022 update on diagnosis,risk stratification,and management[J].American J Hematol,2022,97(8):1086-1107. [3] ZANWAR S,JACOB E K,GREINER C,et al.The immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant[J].Blood Cancer J,2023,13(1):151. [4] MALKAN U Y,DEMIROGLU H,BUYUKASIK Y,et al.Comparison of single and double autologous stem cell transplantation in multiple myeloma patients[J].Open Med(Wars),2021,16(1):192-197. [5] RODRIGUEZ-OTERO P,PAIVA B,SAN-MIGUEL J F.Roadmap to cure multiple myeloma[J].Cancer Treat Rev,2021,100:102284. [6] BARLOGIE B,JAGANNATH S,VESOLE D H,et al.Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma[J].Blood,1997,89(3):789-793. [7] SONNEVELD P,VAN DER HOLT B,SEGEREN C M,et al.Intermediate-dose melphalan compared with myeloablative treatment in multiple myeloma:Long-term follow-up of the Dutch Cooperative Group HOVON 24 trial[J].Haematologica,2007,92(7):928-935. [8] MAI E K,BENNER A,BERTSCH U,et al.Single versus tandem high-dose melphalan followed by autologous blood stem cell transplantation in multiple myeloma:Long-term results from the phase III GMMG-HD2 trial[J].Br J Haematol,2016,173(5):731-741. [9] BLOCKA J,HIELSCHER T,GOLDSCHMIDT H,et al.Response improvement rather than response status after first autologous stem cell transplantation is a significant prognostic factor for survival benefit from tandem compared with single transplantation in multiple myeloma patients[J].Biol Blood Marrow Transplant,2020,26(7):1280-1287. [10] ATTAL M,LAUWERS-CANCES V,HULIN C,et al.Lenalidomide,bortezomib,and dexamethasone with transplantation for myeloma[J].N Engl J Med,2017,376(14):1311-1320. [11] STADTMAUER E A,PASQUINI M C,BLACKWELL B,et al.Comparison of autologous hematopoietic cell transplant(autoHCT),bortezomib,lenalidomide(len)and dexamethasone(RVD)consolidation with len maintenance(ACM),tandem autohct with len maintenance(TAM)and autohct with len maintenance(AM)for up-front treatment of patients with multiple myeloma(MM):Primary results from the randomized phase III trial of the blood and marrow transplant clinical trials network(BMT CTN 0702-StaMINA trial)[J].Blood,2016,128(22):LBA-1-LBA-1. [12] CAVO M,GOLDSCHMIDT H,ROSINOL L,et al.Double vs single autologous stem cell transplantation for newly diagnosed multiple myeloma:Long-term follow-up(10-years)analysis of randomized phase 3 studies[J].Blood,2018,132:124. [13] ZAMAGNI E,BARBATO S,CAVO M.How I treat high-risk multiple myeloma[J].Blood,2022,139(19):2889-2903. [14] SONNEVELD P,AVET-LOISEAU H,LONIAL S,et al.Treatment of multiple myeloma with high-risk cytogenetics:a consensus of the International Myeloma Working Group[J].Blood,2016,127(24):2955-2962. [15] MOREAU P,KUMAR S K,SAN MIGUEL J,et al.Treatment of relapsed and refractory multiple myeloma:Recommendations from the International Myeloma Working Group[J].Lancet Oncol,2021,22(3):e105-e118. [16] KUMAR S K,CALLANDER N S,HILLENGASS J,et al.NCCN guidelines insights:Multiple myeloma,version 1.2020[J].J Natl Compr Canc Netw,2019,17(10):1154-1165. [17] MO C C,HARTLEY-BROWN M A,MIDHA S,et al.Upfront or deferred autologous stem cell transplantation for newly diagnosed multiple myeloma in the era of triplet and quadruplet induction and minimal residual disease/risk-adapted therapy[J].Cancers,2023,15(24):5709. [18] RICHARDSON P G,JACOBUS S J,WELLER E A,et al.Triplet therapy,transplantation,and maintenance until progression in myeloma[J].N Engl J Med,2022,387(2):132-147. [19] CHEN Y H,FOGEL L,SUN A Y,et al.The efficacy and safety of tandem transplant versus single stem cell transplant for multiple myeloma patients:A systematic review and meta-analysis[J].Diagnostics(Basel),2024,14(10):1030. [20] TACCHETTI P,PANTANI L,PATRIARCA F,et al.Bortezomib,thalidomide,and dexamethasone followed by double autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma(GIMEMA-MMY-3006):Long-term follow-up analysis of a randomised phase 3,open-label study[J].Lancet Haematol,2020,7(12):e861-e873. [21] GOLDMAN-MAZUR S,JURCZYSZYN A,CASTILLO J J,et al.Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients[J].Leuk Lymphoma,2020,61(8):1885-1893. [22] TOUZEAU C,PERROT A,HULIN C,et al.Daratumumab,carfilzomib,lenalidomide,and dexamethasone with tandem transplant for high-risk newly diagnosed myeloma[J].Blood,2024,143(20):2029-2036. [23] CAVO M,SALWENDER H,ROSIÑOL L,et al.Double vs single autologous stem cell transplantation after bortezomib-based induction regimens for multiple myeloma:An integrated analysis of patient-level data from phase European III studies[J].Blood,2013,122(21):767. [24] CAVO M,PANTANI L,PETRUCCI M T,et al.Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma[J].Blood,2012,120(1):9-19. [25] MORGAN G J,GREGORY W M,DAVIES F E,et al.The role of maintenance thalidomide therapy in multiple myeloma:MRC Myeloma IX results and meta-analysis[J].Blood,2012,119(1):7-15. [26] WU S Q,LI X F,QIU Z J,et al.Comparison of tandem and single autologous stem cell transplantation in multiple myeloma:a retrospective propensity score-matching study[J].Blood Sci,2025,7(2):e00235. [27] LIU E,SUDHA P,BECKER N,et al.Identifying novel mechanisms of biallelic TP53 loss refines poor outcome for patients with multiple myeloma[J].Blood Cancer J,2023,13(1):144. [28] SHAH V,JOHNSON D C,SHERBORNE A L,et al.SubclonalTP53copy number is associated with prognosis in multiple myeloma[J].Blood,2018,132(23):2465-2469. [29] VILLALBA A,GONZALEZ-RODRIGUEZ A P,ARZUAGA-MENDEZ J,et al.Single versus tandem autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma and high-risk cytogenetics.A retrospective,open-label study of the PETHEMA/Spanish Myeloma Group(GEM)[J].Leuk Lymphoma,2022,63(14):3438-3447. [30] CAVO M,GAY F M,PATRIARCA F,et al.Double autologous stem cell transplantation significantly prolongs progression-free survival and overall survival in comparison with single autotransplantation in newly diagnosed multiple myeloma:An analysis of phase 3 EMN02/HO95 study[J].Blood,2017,130:401. [31] SECKINGER A,SALWENDER H,MARTIN H,et al.Molecular long-term analysis of the GMMG-HD4 trial in multiple myeloma-patterns of association of chromosomal aberrations with response and proliferation determining survival in selecting treatments in view of limited resources in low-and middle-income countries[J].Int J Mol Sci,2024,25(12):6431. [32] TAO Y,JIN S,YANG D,et al.Real-world advantage and challenge of post-autologous stem cell transplantation MRD negativity in high-risk patients with double-hit multiple myeloma[J].BMC Cancer,2024,24(1):406. [33] TERRAGNA C,POLETTI A,SOLLI V,et al.Multi-dimensional scaling techniques unveiled gain1 q&loss13 q co-occurrence in Multiple Myeloma patients with specific genomic,transcriptional and adverse clinical features[J].Nat Commun,2024,15(1):1551. [34] FERLA V,FARINA F,PERINI T,et al.Monoclonal antibodies in smoldering multiple myeloma and monoclonal gammopathy of undetermined significance:Current status and future directions[J].Pharmaceuticals(Basel),2024,17(7):901. [35] SCHMIDT T M,BARWICK B G,JOSEPH N,et al.Gain of Chromosome 1 q is associated with early progression in multiple myeloma patients treated with lenalidomide,bortezomib,and dexamethasone[J].Blood Cancer J,2019,9(12):94. [36] TANG H K K,FUNG C Y,MORGAN G J,et al.The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain[J].Ther Adv Hematol,2022,13:20406207221082043. [37] ROSIÑOL L,ORIOL A,TERUEL A I,et al.Superiority of bortezomib,thalidomide,and dexamethasone(VTD)as induction pretransplantation therapy in multiple myeloma:a randomized phase 3 PETHEMA/GEM study[J].Blood,2012,120(8):1589-1596. [38] NEBEN K,JAUCH A,BERTSCH U,et al.Combining information regarding chromosomal aberrations t(4;14)and del(17p13)with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation[J].Haematologica,2010,95(7):1150-1157. [39] VARMA A,SUI D,MILTON D R,et al.Outcome of multiple myeloma with chromosome 1 q gain and 1 p deletion after autologous hematopoietic stem cell transplantation:Propensity score matched analysis[J].Biol Blood Marrow Transplant,2020,26(4):665-671. [40] LIU N,XIE Z,LI H,et al.The numerous facets of 1q21+ in multiple myeloma:Pathogenesis,clinicopathological features,prognosis and clinical progress(Review)[J].Oncol Lett,2024,27(6):258. [41] GAGELMANN N,EIKEMA D J,KOSTER L,et al.Tandem autologous stem cell transplantation improves outcomes in newly diagnosed multiple myeloma with extramedullary disease and high-risk cytogenetics:A study from the chronic malignancies working party of the European society for blood and marrow transplantation[J].Biol Blood Marrow Transplant,2019,25(11):2134-2142. [42] MANGIACAVALLI S,POMPA A,FERRETTI V,et al.The possible role of burden of therapy on the risk of myeloma extramedullary spread[J].Ann Hematol,2017,96(1):73-80. [43] GAGELMANN N,EIKEMA D J,IACOBELLI S,et al.Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation:a study from the Chronic Malignancies Working Party of the EBMT[J].Haematologica,2018,103(5):890-897. [44] KRÖGER N,WULF G,HEGENBART U,et al.Autologous-allogeneic versus autologous tandem stem cell transplantation and maintenance therapy with thalidomide for multiple myeloma patients under 60 years of age:a prospective,phase II study[J].Haematologica,2024,109(5):1469-1479. [45] YIN X,TANG L,FAN F,et al.Allogeneic stem-cell transplantation for multiple myeloma:a systematic review and meta-analysis from 2007 to 2017[J].Cancer Cell Int,2018,18:62. [46] KRISHNAN A,PASQUINI M C,LOGAN B,et al.Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma(BMT CTN 0102):a phase 3 biological assignment trial[J].Lancet Oncol,2011,12(13):1195-1203. [47] KHARFAN-DABAJA M A,HAMADANI M,RELJIC T,et al.Comparative efficacy of tandem autologous versus autologous followed by allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma:a systematic review and meta-analysis of randomized controlled trials[J].J Hematol Oncol,2013,6:2. [48] MAFFINI E,STORER B E,SANDMAIER B M,et al.Long-term follow up of tandem autologous-allogeneic hematopoietic cell transplantation for multiple myeloma[J].Haematologica,2019,104(2):380-391. [49] CHARI A,KAUFMAN J L,LAUBACH J,et al.Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma:Final analysis of clinically relevant subgroups in GRIFFIN[J].Blood Cancer J,2024,14(1):107. |