血清防御素5与重症急性胰腺炎患者合并胰周坏死感染的相关性研究

doi:10.3870/j.issn.1672-8009.2025.06.011

医学分子生物学杂志 ›› 2025, Vol. 22 ›› Issue (6): 607-611.doi: 10.3870/j.issn.1672-8009.2025.06.011

血清防御素5与重症急性胰腺炎患者合并胰周坏死感染的相关性研究

张虹燕¹, 陈晖²

昆山市中医医院¹重症医学科,²急诊重症监护室江苏省昆山市,215300

收稿日期:2025-04-24 出版日期:2025-11-30 发布日期:2025-12-25
通讯作者: 陈晖(E-mail:15950188672@163.com)
基金资助:
2022年江苏省中医药科技发展计划项目(No.MS2022087)

Correlation of Serum Defensin 5 Level and Severe Acute Pancreatitis Complicated with Peripancreatic Necrosis

ZHANG Hongyan¹, CHEN Hui²

¹Department of Critical Care Medicine,²Department of Emergency Intensive Care Unit,Kunshan Hospital of Traditional Chinese Medicine,Kunshan,Jiangsu,215300,China

Received:2025-04-24 Online:2025-11-30 Published:2025-12-25
Contact: CHEN Hui(E-mail:15950188672@163.com)
Supported by:
2022 Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program Project(No.MS2022087)

摘要/Abstract

摘要： 目的研究血清防御素5(defensin 5)水平对重症急性胰腺炎(severe acute pancreatitis,SAP)患者合并胰周坏死感染的关系。方法选择2020年5月~2023年12月昆山市中医医院收治的224例SAP患者进行回顾性研究,根据是否发生胰周坏死感染分为坏死感染组(n=96)和非坏死感染组(n=128),比较两组间一般资料及入院后24 h内血清防御素5水平、实验室指标的差异,采用logistic回归分析SAP合并胰周坏死感染的影响因素,采用受试者工作特征(ROC)曲线分析胰周坏死感染的诊断指标。结果坏死感染组的血清防御素5和血钙水平低于非坏死感染组,发病至入院时间、C反应蛋白(C-reactive protein,CRP)水平及降钙素原(procalcitonin,PCT)水平高于非坏死感染组,差异有统计学意义(P<0.05);经logistic回归分析显示,血清防御素5水平、发病至入院时间、血钙水平、CRP和PCT水平是发生胰周坏死感染的影响因素(P<0.05);ROC曲线分析显示,血清防御素5水平、发病至入院时间、血钙水平、CRP和PCT水平单独及联合均对SAP合并胰周坏死感染具有诊断价值,联合诊断的灵敏度82.81 %、特异度96.99 %。结论血清防御素5水平降低与SAP合并胰周坏死感染相关,防御素5水平联合发病至入院时间、血钙水平、CRP和PCT水平对SAP合并胰周坏死感染具有较好的诊断效能。

关键词: 重症急性胰腺炎, 胰周坏死感染, 防御素5, 影响因素, 诊断

Abstract: Objective To study the correlation of serum defensin 5 level and severe acute pancreatitis(SAP)complicated with peripancreatic necrosis. Methods A retrospective study was conducted on 224 SAP patients admitted to Kunshan Hospital of Traditional Chinese Medicine from May 2020 to December 2023,and they were divided into peripancreatic necrosis group(n=96)and non-peripancreatic necrosis group(n=128)according to whether peripancreatic necrosis infection occurred.Compare the differences in general characteristics,and serum defensin 5 levels and laboratory indicators within 24 hours of admission between the two groups.Logistic regression was used to analyze the influencing factors of SAP combined with peripancreatic necrosis,and receiver operating characteristics(ROC)curve was used to analyze the diagnostic indicators of peripancreatic necrosisn. Results The levels of serum defensin 5 and serum calcium in the peripancreatic necrosis group were lower than those in the non-peripancreatic necrosis group,and the time from onset to hospital admission,the levels of C-reactive protein(CRP)and procalcitonin(PCT)were higher than those in the non-peripancreatic necrosis group(P<0.05).Logistic regression analysis showed that the level of serum defencin 5,the time from onset to admission,and the levles of serum calcium,CRP and PCT were the influencing factors of peripancreatic necrosis(P<0.05).ROC curve analysis demonstrated that serum defensin 5 level,time from symptom onset to admission,serum calcium levels,CRP,and PCT levels—both individually and in combination—possess diagnostic value for SAP complicated by peripancreatic necrosis infection.The combined diagnostic approach achieved a sensitivity of 82.81 % and a specificity of 96.99 %. Conclusion The decrease of serum defensin 5 level is related to SAP complicated with peripancreatic necrosis.The combination of defensin 5 and time from onset to hospital admission,serum calcium,CRP and PCT have better diagnostic efficacy for SAP complicated with peripancreatic necrosis.

Key words: severe acute pancreatitis, peripancreatic necrosis, defensin 5, influencing factors, diagnosis

中图分类号:

R657.5

张虹燕, 陈晖. 血清防御素5与重症急性胰腺炎患者合并胰周坏死感染的相关性研究[J]. 医学分子生物学杂志, 2025, 22(6): 607-611.

ZHANG Hongyan, CHEN Hui. Correlation of Serum Defensin 5 Level and Severe Acute Pancreatitis Complicated with Peripancreatic Necrosis[J]. Journal of Medical Molecular Biology, 2025, 22(6): 607-611.

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血清防御素5与重症急性胰腺炎患者合并胰周坏死感染的相关性研究

Correlation of Serum Defensin 5 Level and Severe Acute Pancreatitis Complicated with Peripancreatic Necrosis

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