关键词: 蛛网膜下腔出血, 星形胶质细胞, 早期脑损伤, 迟发性脑缺血

Abstract: Subarachnoid hemorrhage (SAH) is a cerebrovascular disease that is characterizedby a high rate of disability and mortality. Astrocytes play a crucial role in brain injury and recovery following SAH. This paper summarizes the activation and polarization of astrocytes after SAH, their participation and mediation in early brain injury and delayed cerebral ischemia after SAH, and the extensive crosstalk between astrocytes and other brain cells, such as neurons, microglia, and vascular endothelial cells after SAH. In addition, the relevant targets and therapeutic methods for regulating astrocyte function after SAH are also listed here, offering some novel strategies for future translational therapies to alleviate the severe consequences of SAH.

Key words: subarachnoid hemorrhage, astrocytes, early brain injury, delayed cerebral ischemia