关键词: 细粒棘球绦虫, 髓样分化因子 88, 白介素-23, 肝再生

Abstract: Objective To explore the influence of Echinococcus granulosus, (E. granulosus)infection on liver regeneration in hepatectomy model in mice, and to investigate the expression ofMyD88 / IL-23 in the liver regeneration of E. granulosus-infected mice post hepatectomy and its significance. Methods A mouse model with 70 % hepatectomy following subcutaneous infection of E- . granulosus was established. A total of 18 E. granulosus-infected mice and 18 healthy mice as controls were chosen for the surgery. The amount and rate of liver regeneration at different time points post-surgery in mice between the two groups were analyzed. The expression levels of MyD88 and IL-23 in mouse serum at different time points were measured by ELISA. The changes in hepatic functionindicators AST and ALT were also monitored. Results Compared to the control mice, the E-. granulosus -infected mice demonstrated decreased liver regeneration amount and regeneration ratepost hepatectomy, with significant differences apparent at the time points of 12 hours, 1 day, and2 days post-surgery. In comparison to the control mice, the E. granulosus-infected mice exhibitedmarkedly increased levels of AST and ALT in peripheral blood 1 day post-surgery, and notably increased levels of MyD88 and IL-23 2 hours post-surgery. Conclusions E. granulosus infection significantly decelerates the liver regeneration process following hepatectomy in mice, which maythrough increasing the levels of MyD88 and IL-23.

Key words: