CORO1B基因与肿瘤关系的研究进展*

doi:10.3870/j.issn.1672-0741.25.11.017

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (4): 593-596.doi: 10.3870/j.issn.1672-0741.25.11.017

CORO1B基因与肿瘤关系的研究进展^*

鞠由华^1,2, 曾筱曲^1,2, 梁有鑫^1,2, 周宇^1△

¹广东医科大学附属医院消化内科,湛江 524000
²广东医科大学第一临床医学院,湛江 524023

收稿日期:2025-11-11 出版日期:2026-08-15 发布日期:2026-07-28
通讯作者: ^△E-mail:ahdg2005@126.com
作者简介:鞠由华,女,1999年生,硕士研究生,E-mail:17562028626@163.com
基金资助:
^*广东省自然科学基金资助项目(No.2023A1515010530)

Research Progress of Correlation Between CORO1B Gene and Tumor

Ju Youhua^1,2, Zeng Xiaoqu^1,2, Liang Youxin^1,2, et al

¹Department of Gastroenterology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China
²The First Clinical School of Medicine,Guangdong Medical University,Zhanjiang 524023,China

Received:2025-11-11 Online:2026-08-15 Published:2026-07-28
Contact: ^△E-mail:ahdg2005@126.com

摘要/Abstract

摘要： 冠蛋白1B(CORO1B)基因编码的蛋白是一种肌动蛋白结合蛋白,其ser-2位点被蛋白激酶C(PKC)磷酸化后,可调节肌动蛋白肌丝的聚合和解聚,进而参与细胞骨架重组、细胞运动、迁徙和转移等重要病理、生理过程。有研究发现CORO1B基因与多种肿瘤的发生、发展有关。该文对CORO1B基因与肿瘤关系的研究进展进行综述。

关键词: 冠蛋白1 B基因, 肌动蛋白, 肿瘤

Abstract: The protein encoded by Coronin 1B(CORO1B)gene is an actin-binding protein,the serine-2 residue of which can be phosphorylated by protein kinase C(PKC)to regulate the polymerization and depolymerization of actin,thereby participating in many important pathological and physiological processes,like cytoskeletal reorganization,cell motility,migration,and metastasis.Numerous studies have also found that the CORO1B gene is associated with the occurrence and development of various types of tumors.This article reviews the research progress on the relationship between the CORO1B gene and tumors.

Key words: CORO1B, actin, tumor

中图分类号:

R730.2

鞠由华, 曾筱曲, 梁有鑫, 周宇. CORO1B基因与肿瘤关系的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(4): 593-596.

Ju Youhua, Zeng Xiaoqu, Liang Youxin, et al. Research Progress of Correlation Between CORO1B Gene and Tumor[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(4): 593-596.

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CORO1B基因与肿瘤关系的研究进展^*

Research Progress of Correlation Between CORO1B Gene and Tumor

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