蛋白质Neddylation修饰及其在肿瘤中的作用*

doi:10.3870/j.issn.1672-0741.25.10.011

摘要/Abstract

摘要： 拟素化修饰(neddylation)是一种重要的类泛素化的翻译后修饰,是由3种关键酶E1、E2和E3级联触发的一种可逆的蛋白修饰过程。拟素化修饰通过影响靶蛋白的稳定性、构象、亚细胞定位以及功能,进而调控细胞的多种生物学进程。新近研究揭示,拟素化修饰在肿瘤中普遍过度激活,其枢纽分子与肿瘤细胞增殖、侵袭迁移及免疫逃逸等一系列恶性表型紧密关联,从而为抗肿瘤干预策略开辟了全新的潜在靶点。该文围绕拟素化修饰展开系统综述,梳理其在肿瘤发生与演进中的功能角色与分子机制,并对其在肿瘤治疗中的潜在应用前景进行深入剖析。

关键词: 拟素化修饰, NEDD8蛋白, MLN4924, 肿瘤

Abstract: Neddylation is a significant post-translational modification that resembles ubiquitination and is a reversible protein modification process that is initiated by the cascade of three essential enzymes:E1,E2,and E3.By altering the stability,shape,subcellular localization,and function of target proteins,neddylation regulate a number of cellular biological processes.According to recent research,neddylation is generally overactivated in tumors,and its hub molecules are intimately associated with a number of malignant characteristics,including immune evasion,invasion and migration,and tumor cell proliferation.This opens up new potential targets for anti-tumor intervention efforts.This study focuses on a systematic analysis of neddylation,classifies its molecular mechanism and functional significance in carcinogenesis and evolution,and thoroughly examines its possible applications in tumor treatment.

Key words: neddylation, NEDD8, MLN4924, tumor

中图分类号:

R730

余昌琪, 张铭, 邓正栋, 王剑明. 蛋白质Neddylation修饰及其在肿瘤中的作用^*[J]. 华中科技大学学报（医学版）, 2026, 55(3): 416-422.

Yu Changqi, Zhang Ming, Deng Zhengdong et al. Protein Neddylation and Its Role in Tumor[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(3): 416-422.

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蛋白质Neddylation修饰及其在肿瘤中的作用^*

Protein Neddylation and Its Role in Tumor

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