Abstract: Diabetic angiopathy is the main cause of disability and death in diabetes. However, strategies for the prevention and treatment of diabetic angiopathy have not achieved ideal results. Mechanistic target of rapamycin kinase ( mTOR) is a serine / threonine kinase presented in eukaryotes and plays an important role in various biological processes. A large number of studies have found that mTOR could participate in the occurrence and progress of diabetic angiopathy by regulating cell proliferation, apoptosis, autophagy, oxidative stress and inflammatory responses. This article reviews the effect and related mechanisms of mTOR on diabetic atherosclerosis, diabetic nephropathy and diabetic retinopathy, and provides a new insight for the prevention and treatment of diabetic angiopathy. 

Key words: mechanistic target of rapamycin kinase, diabetic angiopathy, diabetic atherosclerosis, diabetic retinopathy, diabetic nephropathy