Advances in Diagnosis and Management of Porto-Sinusoidal Vascular Disease

doi:10.3870/j.issn.1672-8009.2026.05.014

Abstract

Abstract: Porto-sinusoidal vascular disease （PSVD） is a recently redefined vascular liver disorder characterized by structural injury of the porto-sinusoidal microcirculation and consequent complications related to portal hypertension. With advances in histopathology, transcriptomics, genetic studies, and medical imaging technologies, the diagnostic approach to PSVD has evolved from a primarily exclusion-based clinical diagnosis toward a precision-oriented strategy integrating pathological assessment, molecular profiling, and non-invasive evaluation. This review summarizes recent progress in the pathophysiological and molecular mechanisms, histopathological features, clinical manifestations, molecular and non-invasive diagnostic clues, and therapeutic strategies of PSVD. Furthermore, we discuss future perspectives regarding the development of stratified diagnostic models and mechanism-directed therapeutic approaches for this disease.

Key words: porto-sinusoidal vascular disease, portal hypertension, molecular mechanisms, biomarkers

CLC Number:

R575.2

BIAN Hao, WEI Hongshan. Advances in Diagnosis and Management of Porto-Sinusoidal Vascular Disease[J]. Journal of Medical Molecular Biology, 2026, 23(5): 587-591.

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