Effect of miR-330-3p/LHX6 Axis on Proliferation,Migration and Invasion of Endometrial Cancer Cells

doi:10.3870/j.issn.1672-8009.2026.02.011

Abstract

Abstract: Objective To explore the effect of miR-330-3p on proliferation,migration,and invasion of endometrial cancer by targeting LIM homeobox 6(LHX6).Methods The clinical significance of miR-330-3p and LHX6 in endometrial cancer was analyzed by TCGA database.The binding site between miR-330-3p and LHX6 was predicted by Starbase and was then validated.HEC108 and Ishikawa cell lines with miR-330-3p overexpression or miR-330-3p/LHX6 overexpression were constructed to observe cells proliferation,migration and invasion.The xenograft nude mice model with miR-330-3p overexpressed HEC108 cells were constructed to observe the growth of transplanted tumors.Results The expression level of miR-330-3p was increased,while the expression level of LHX6 was decreased in endometrial cancer tissues,and miR-330-3p could inhibit the expression of LHX6.Overexpression of miR-330-3p could promote the proliferation,migration and invasion of HEC108 and Ishikawa cells and the growth of transplanted tumors.Overexpression of LHX6 could partially reverse the effect of miR-330-3p overexpression in cells.Conclusion miR-330-3p can promote proliferation,migration and invasion of endometrial cancer by inhibiting the expression of LHX6.

Key words: endometrial cancer, microRNA-330-3p, LIM homeobox 6

CLC Number:

R737.33

QIAO Meiling, ZHANG Lihua, ZHAO Xiaoyang, WEI Lei. Effect of miR-330-3p/LHX6 Axis on Proliferation,Migration and Invasion of Endometrial Cancer Cells[J]. Journal of Medical Molecular Biology, 2026, 23(2): 186-193.

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