Abstract: Aspergillus fumigatus (A. fumigatus) is a common opportunistic pathogen. Its sporesare abundant in the human environment and are the main cause of invasive aspergillosis, with highinfection rate and mortality rate. The ability of A. fumigatus to resist and adapt to adverse environments is closely related to their virulence and is the key to the treatment of A. fumigatus infection. This review introduces the signal transduction pathways, including the unfolded protein response pathway, high osmolarity glycerolpathway, cell wall integrity pathway and calcium-calcineurin pathway, in A. fumigatus under different stress conditions and their effects on the growth,virulence and resistance to antifungal drugs. It provides new ideas for the development of innovative drugs for the treatment of invasive aspergillosis.

Key words: Aspergillus fumigatus, stress, virulence, signal transduction