Abstract: Inflammatory bowel disease ( IBD) is a class of chronic recurrent gastrointestinalinflammatory diseases caused by inflammation and immune system disorders. Its pathogenesis is complex, and the immune system attacks the lining of the intestine, causing chronic inflammation and tissue damage. As a typical inflammatory disease, multiple immune cell types are involved in the pathogenesis of IBD. Among them, macrophages are thought to play a pivotal role. Intestinal macrophages are an important part of maintaining intestinal immune homeostasis and inhibiting the inflammatory response, which is of great significance for the treatment of inflammatory bowel disease. Given that macrophages can coordinate inflammation resolution and tissue repair, they are currently considered an attractive target for developing new treatments for inflammatory bowel disease. This review summarizes the research progress of immunomodulatory role of intestinal macrophages in IBD, so as to provide reference for the research of pathogenesis and the clinical treatment of IBD.

Key words: inflammatory bowel disease, macrophage, intestinal, homeostasis