Abstract: Psoriasis is a common chronic and recurrent inflammatory skin disease. The disorder of keratinocyte (KC) proliferation and differentiation is one of its pathogeneses, but the underlying molecular mechanisms are still largely unknown. The extracellular signal regulated kinase (ERK) signaling pathway is reported to play an important role in KC proliferation and differentiation. MicroRNA (miRNA), long non-coding RNA (lncRNA), cytokines and other upstream molecules of ERK signaling pathway are also involved in the process. The purpose of this article is to review the mechanism of ERK signaling pathway in hyperproliferation of KCs in psoriasis

Key words: psoriasis, keratinocyte, ERK mitogen-activated protein kinase, signaling pathway