Abstract: N⁶ -methyladenosine ( m6A) modification is a post-transcriptional change of RNA molecule. m6A was first discovered in cell mRNA in 1970s, but the extensive investigation on m6A modification did not begin until the genome-wide m6A localization method was developed. The role of m6A in regulating mRNA and its functional importance in various cell types have been verified in many studies, and the mechanism of m6A in regulating gene expression in a variety of physiological processes has been increasingly studied recently. In this review, we summarized recent advances in m 6A modification in immune response, and discussed the regulatory role of m6A modification in innate and adaptive immune responses, and immune system development. 

Key words: N⁶-methyladenosine, RNA modification, immune system