医学分子生物学杂志 ›› 2024, Vol. 21 ›› Issue (5): 497-500.doi: 10.3870/j.issn.1672-8009.2024.05.018

• 综述 • 上一篇    

黄芩成分及其中药复方制剂抗白念珠菌感染的机制研究进展 #br#

  

  1. 山西医科大学第二临床医学院皮肤性病科 太原市, 030001
  • 出版日期:2024-09-30 发布日期:2024-10-25

Research Progress on Mechanism of Scutellaria baicalensis and Its Compounds Preparations against Candida albicans Infection #br#

  1. Department of Dermatology and Venereal Disease, the Second Hospital of Shanxi Medical University, Taiyuan, 030001, China
  • Online:2024-09-30 Published:2024-10-25

摘要:

近年来, 新型冠状病毒肺炎大流行导致念珠菌病发病率显著增加, 白念珠菌感染及常用治疗药
物的耐药问题已成为日益严重的全球公共卫生问题黄芩提取物其一些单体成分及其复方在实验以及临床中被证明有良好的抗白念珠菌活性, 但机制十分复杂, 可能与抑制黏附和侵袭影响生物膜形成诱导细胞凋亡破坏钙稳态破坏糖酵解抑制外排泵抗炎提高免疫等有关

关键词:

白念珠菌, 黄芩, 黄芩素, 黄芩苷


Abstract: In recent years, the incidence of candidiasis has increased significantly due to the COVID-19 pandemic. Candida albicans infection and resistance of commonly used therapeutic drugs have become increasingly serious public health problems globally. The extract of Scutellaria baicalensis, its monomer components and the traditional Chinese medicine compounds preparations have been proved to have good anti- Candida albicans activities in experiments and clinics. However, themechanisms seem to be very complex, which may be related to inhibiting adhesion and invasion, affecting biofilm formation, inducing apoptosis, disrupting calcium homeostasis, disrupting glycolysis, inhibiting effecting pump, fighting inflammation and improving immunity.

Key words: Candida albicans , ,  , Scutellaria baicalensis,  , baicalein, baicalin

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