关键词: 宫颈低度鳞状上皮内病变, 病变进展, Keratin17, 人乳头瘤病毒 E6 / E7

Abstract: Objective To study the predictive value of Keratin17 (Krt17) combined with human papillomavirus (HPV) E6 / E7 mRNA in the prognosis of cervical low-grade squamous intraepithelial lesions (LSIL). Methods Patients diagnosed with LSIL from January 2020 to September2021 and completed 24 months of follow-up were selected and grouped according to the histologicalfindings of the lesions at the 24th month of return visit. Patients with LSIL regression or maintenancewere classified as the non-lesion progression group, and patients with LSIL progression to a highergrade were classified as the lesion progression group. The clinical data, Krt17 mRNA expression level and E6 / E7 copy number of the two groups were compared at the time of first diagnosis. The riskfactors of LSIL lesion progression were analyzed by multivariate logistic step-by-step regression, andthe predictive value of Krt17 combined with E6 / E7 on LSIL lesion progression was analyzed by ROCcurve. Results Among the 98 LSIL patients, 19 cases ( 19. 39 % ) progressed and 79 cases(80. 61 % ) did not progress. The age, smoking rate, menopause rate, Krt17 mRNA expressionlevel and E6 / E7 copy number of LSIL patients in the lesion progression group were higher than thosein the non-lesion progression group (P < 0. 05). Multivariate logistic regression analysis showed that age ≥ 45 years, smoking, increased Krt17 mRNA expression level and E6 / E7 copy number were risk factors for the progression of LSIL lesions. ROC curve analysis showed that Krt17 and E6 / E7had predictive value for the progression of LSIL lesions, and the sensitivity and specificity of thecombined prediction of the two indexes were respectively 81. 01 % and 94. 74 % . Conclusion Krt17 combined with HPV E6 / E7 can predict the progression of LSIL lesions.

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