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Abstract: Hypoxia is an intrinsic feature of lung cancer. It affects the metabolism, proliferationand migration of lung cancer through genomic and proteomic regulation, and up-regulates the tolerance of lung cancer to radiotherapy and induces the resistance of lung cancer to chemotherapy and immunotherapy through complex mechanisms, which make it an important factor leading to the poor prognosis of lung cancer. This article reviews the mechanism of hypoxia in the drug resistance of lung cancer and its potential application as a therapeutic target in the clinical treatment of lung cancer.

Key words: hypoxia, lung cancer, drug resistance