ERK 信号通路介导银屑病角质形成细胞过度增殖的调控机制

doi:10.3870/j.issn.1672-8009.2022.03.014

医学分子生物学杂志 ›› 2022, Vol. 19 ›› Issue (3): 257-260.doi: 10.3870/j.issn.1672-8009.2022.03.014

ERK 信号通路介导银屑病角质形成细胞过度增殖的调控机制

1山西医科大学第九临床医学院太原市, 030009 2山西医科大学附属太原市中心医院皮肤科, 免疫性皮肤病干细胞重点实验室太原市, 030009 3山西医科大学公共卫生学院太原市, 030001

出版日期:2022-05-31 发布日期:2022-06-20
基金资助:
山西省医学重点科研项目 (No. 2020XM20)

Regulatory Mechanism of ERK Signaling Pathway-Mediated Keratinocyte Hyperproliferation in Psoriasis

1 The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030009, China 2 Department of Dermatology, Taiyuan Key Laboratory of Stem Cell for Immunological Dermatosis, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, 030009, China 3 School of Public Health, Shanxi Medical University, Taiyuan, 030001, China

Online:2022-05-31 Published:2022-06-20

摘要/Abstract

摘要： 银屑病是常见的慢性、复发性、炎症性皮肤病, 角质形成细胞 ( keratinocyte, KC) 增殖分化失调作为其发病原因之一, 具体机制尚未明确。细胞外信号调节激酶 ( extracellular signal regulated kinase, ERK) 信号通路在其中发挥着重要作用, 微小 RNA (microRNA, miRNA)、长链非编码 RNA ( lncRNA)、细胞因子等作为 ERK 信号通路的上游分子参与调控银屑病表皮角质形成细胞的增殖与分化过程。文章旨在对这一通路在银屑病角质形成细胞过度增殖中的作用机制做一综述。

关键词: 银屑病, 角质形成细胞, ERK 丝裂原活化蛋白激酶, 信号通路

Abstract: Psoriasis is a common chronic and recurrent inflammatory skin disease. The disorder of keratinocyte (KC) proliferation and differentiation is one of its pathogeneses, but the underlying molecular mechanisms are still largely unknown. The extracellular signal regulated kinase (ERK) signaling pathway is reported to play an important role in KC proliferation and differentiation. MicroRNA (miRNA), long non-coding RNA (lncRNA), cytokines and other upstream molecules of ERK signaling pathway are also involved in the process. The purpose of this article is to review the mechanism of ERK signaling pathway in hyperproliferation of KCs in psoriasis

Key words: psoriasis, keratinocyte, ERK mitogen-activated protein kinase, signaling pathway

中图分类号:

R758. 63

杨艳妮 , 李俊琴 , 赵子葳 , 李新华. ERK 信号通路介导银屑病角质形成细胞过度增殖的调控机制[J]. 医学分子生物学杂志, 2022, 19(3): 257-260.

YANG Yanni , LI Junqin , ZHAO Ziwei , LI Xinhua . Regulatory Mechanism of ERK Signaling Pathway-Mediated Keratinocyte Hyperproliferation in Psoriasis[J]. Journal of Medical Molecular Biology, 2022, 19(3): 257-260.

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ERK 信号通路介导银屑病角质形成细胞过度增殖的调控机制

Regulatory Mechanism of ERK Signaling Pathway-Mediated Keratinocyte Hyperproliferation in Psoriasis

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