铁死亡与肌萎缩侧索硬化症相关机制研究进展

doi:10.3870/j.issn.1672-8009.2025.06.014

摘要/Abstract

摘要： 肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一种致命的神经系统变性疾病,选择性运动神经元死亡是其显著病理特点。诱发ALS神经元死亡的机制错综复杂,目前尚无有效的治疗方案,深入探索潜在疾病机制,寻找可能延缓疾病进展、延长生存期并最终减轻疾病负担的神经保护剂迫在眉睫。铁死亡(ferroptosis)是一种由铁离子介导的程序性细胞死亡模式,其通过脂质过氧化和氧化应激导致神经元损伤。近年研究揭示,铁死亡与ALS的病理机制密切相关,可能成为潜在治疗靶点。文章综述了铁死亡的分子机制、ALS的病理特征及两者之间的潜在联系,探讨了靶向铁死亡治疗ALS的临床试验最新进展,以期开辟ALS治疗新途径。

关键词: 肌萎缩侧索硬化, 铁死亡, 脂质过氧化

Abstract: Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease,and the selective death of motor neurons is its prominent pathological feature.The mechanisms triggering the death of ALS neurons are intricate.Currently,there is no effective treatment plan.It is urgent to deeply explore the potential disease mechanisms and search for neuroprotective agents that may delay disease progression,extend survival,and ultimately reduce the disease burden.Ferroptosis is a programmed cell death mode mediated by iron ions,which causes neuronal damage through lipid peroxidation and oxidative stress.Recent studies have revealed that ferroptosis is closely related to the pathological mechanism of ALS and may become a potential therapeutic target.This article reviews the molecular mechanisms of ferroptosis,pathological characteristics of ALS,and potential connections between the two.It also explores the latest advances in clinical trials targeting ferroptosis for the treatment of ALS,with the aim of opening up new avenues for ALS treatment.

Key words: amyotrophic lateral sclerosis, ferroptosis, lipid peroxidation

中图分类号:

R743.35

李淑杰, 齐艳, 孙支唐. 铁死亡与肌萎缩侧索硬化症相关机制研究进展[J]. 医学分子生物学杂志, 2025, 22(6): 623-629.

LI Shujie, QI Yan, SUN Zhitang. Research Progress on Ferroptosis Associated Mechanisms in Amyotrophic Lateral Sclerosis[J]. Journal of Medical Molecular Biology, 2025, 22(6): 623-629.

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