复方苦参汤灌肠治疗放射性肠炎临床疗效观察*

doi:10.3870/j.issn.1672-0741.25.12.037

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (4): 547-551.doi: 10.3870/j.issn.1672-0741.25.12.037

复方苦参汤灌肠治疗放射性肠炎临床疗效观察^*

赵志强, 余周歆, 喻婷, 范恒^△

华中科技大学同济医学院附属协和医院中医科,武汉 430022

收稿日期:2025-12-24 出版日期:2026-08-15 发布日期:2026-07-28
通讯作者: ^△E-mail:fanheng009@aliyun.com
作者简介:赵志强,男,2001年生,硕士研究生,E-mail:2261938649@qq.com
基金资助:
^*国家重点研发计划“中医药现代化”重点专项项目(No.2025 YFC3508502);湖北省重大疑难项目“全省重大疑难疾病中西医临床协作项目-溃疡性结肠炎”(No.鄂卫办通[2023]2号文)

Clinical Efficacy of Compound Sophora Decoction in the Treatment of Radiation Enteritis

Zhao Zhiqiang, Yu Zhouxin, Yu Ting, et al

Department of Traditional Chinese Medicine,Union Hospital,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022,China

Received:2025-12-24 Online:2026-08-15 Published:2026-07-28
Contact: ^△E-mail:fanheng009@aliyun.com

摘要/Abstract

摘要： 目的研究复方苦参汤灌肠与常规西药联合治疗放射性肠炎的临床效果。方法将华中科技大学附属协和医院中医科2020年1月1日至2024年12月31日收治的95例放射性肠炎患者作为回顾分析对象,将仅接受常规治疗(地塞米松+蒙脱石散),未使用复方苦参汤的患者划分为对照组;接受了常规治疗+复方苦参汤灌肠给药,1次/d,治疗时间持续1周的患者划分为治疗组,总计对照组47例和治疗组48例。治疗完成后,对两组患者的中医症候评分、血清炎症指标以及KPS评分进行对比。结果治疗组症状总缓解率(93.75％)显著高于对照组(78.72％),差异具有统计学意义(P<0.01);两组治疗后中医症候评分、血清炎症指标、KPS评分均明显改善(均P<0.05),且相较于对照组,治疗组的改善程度更为突出,差异具有统计学意义(均P<0.05)。结论采用复方苦参汤灌肠与西药(地塞米松+蒙脱石散)联合治疗放射性肠炎,能够显著缓解患者的临床症状,改善预后,大幅度提升临床治疗效果。

关键词: 放射性肠炎, 复方苦参汤, 灌肠, 临床研究

Abstract: Objective To evaluate the clinical efficacy of Compound Sophora Decoction enema combined with conventional western medicine for the treatment of radiation enteritis.Methods A retrospective analysis was performed on 95 patients with radiation enteritis treated at the Department of Traditional Chinese Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,between January 2020 and December 2024.Patients were divided into control group(n=47,receiving conventional western medicine:dexamethasone and montmorillonite powder)and treatment group(n=48,receiving conventional treatment plus Compound Sophora Decoction enema once daily for one week).Traditional Chinese medicine(TCM)syndrome scores,serum inflammatory markers,and Karnofsky Performance Status(KPS)scores were compared between the two groups post-treatment.Results The overall symptom remission rate was significantly higher in the treatment group than in the control group(93.75%vs.78.72%,P<0.01).Following the treatment,both groups demonstrated significant improvements in TCM syndrome scores,serum inflammatory markers,and KPS scores(all P<0.05).Furthermore,the treatment group exhibited significantly greater improvements in these parameters compared with the control group(all P<0.05).Conclusion Compound Sophora Decoction enema combined with conventional western medicine significantly alleviates clinical symptoms,reduces systemic inflammation,and improves performance status in patients with radiation enteritis,offering a superior therapeutic outcome compared to conventional western medicine alone.

Key words: iradiation enteritis, Compound Sophora Decoction, enema, clinical research

中图分类号:

R818.8

赵志强, 余周歆, 喻婷, 范恒. 复方苦参汤灌肠治疗放射性肠炎临床疗效观察^*[J]. 华中科技大学学报（医学版）, 2026, 55(4): 547-551.

Zhao Zhiqiang, Yu Zhouxin, Yu Ting, et al. Clinical Efficacy of Compound Sophora Decoction in the Treatment of Radiation Enteritis[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(4): 547-551.

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复方苦参汤灌肠治疗放射性肠炎临床疗效观察^*

Clinical Efficacy of Compound Sophora Decoction in the Treatment of Radiation Enteritis

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