泛凋亡在脑缺血再灌注损伤中的研究进展*

doi:10.3870/j.issn.1672-0741.25.12.030

摘要/Abstract

摘要： 脑缺血再灌注损伤（cerebral ischemia-reperfusion injury,CIRI）是指大脑在缺血期间血流受阻,氧气和营养物质耗尽,及时再灌注可恢复大脑的血流/氧合,但也可能导致不可逆的神经损伤。CIRI涉及凋亡、焦亡和坏死性凋亡等多条程序性细胞死亡（programmed cell death,PCD）通路。近年来提出的泛凋亡概念强调三类PCD在炎症性损伤情境下的高度整合与分子串扰,为阐明CIRI中的细胞死亡机制提供了新视角。该文系统概述了泛凋亡的基本概念、不同类型泛凋亡复合体的分子组成与激活机制,并探讨了IRF1、TAK1等关键分子开关的调控作用,重点论述了泛凋亡在CIRI核心病理环节中的主动驱动作用,旨在为开发针对缺血性脑卒中的新型、高效的联合干预策略提供理论依据和潜在靶点。

关键词: 泛凋亡, 泛凋亡复合体, 脑缺血再灌注损伤

Abstract: Cerebral ischemia-reperfusion injury （CIRI） occurs when cerebral blood flow is restored following an ischemia episode. Although oxygen and nutrients are depleted during ischemia, the subsequent rapid reperfusion can paradoxically cause irreversible neuronal damage. CIRI involves multiple programmed cell death （PCD） pathways, including apoptosis, pyroptosis, and necroptosis. The recently proposed concept of PANoptosis highlights the close integration and molecular crosstalk among these three PCD modalities in inflammatory injury settings, offering a novel perspective for elucidating cell death mechanisms in CIRI. This review summarizes the definition of PANoptosis, the molecular composition of PANoptosomes, and the potential roles of different PANoptosome subtypes in CIRI, aiming to open new avenues for therapeutic intervention and drug development.

Key words: PANoptosis, PANoptosome, cerebral ischemia-reperfusion injury

中图分类号:

R743.31

师可馨, 李瑞青, 黄梦玲, 李晶晶, 彭依然, 李欣然, 谷佳妮. 泛凋亡在脑缺血再灌注损伤中的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(5): 765-774.

Shi Kexin, Li Ruiqing, Huang Mengling et al. Research Progress on PANoptosis in Cerebral Ischemia-Reperfusion Injury[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(5): 765-774.

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泛凋亡在脑缺血再灌注损伤中的研究进展^*

Research Progress on PANoptosis in Cerebral Ischemia-Reperfusion Injury

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