Research Progress on Roles of SIRT1 in Hepatic Diseases

doi:10.3870/j.issn.1672-8009.2026.03.010

Abstract

Abstract: Silent information regulator 1(SIRT1),a core member of the Sirtuin family,is an NAD⁺-dependent class Ⅲ histone deacetylase that plays a crucial role in the epigenetic regulatory network.By mediating the deacetylation of a variety of histone and non-histone substrates,SIRT1 broadly regulates key physiological processes such as lipid metabolism,oxidative stress,inflammatory response,and apoptosis.Current studies indicate that dysregulation or functional impairment of SIRT1 is closely associated with the occurrence and progression of liver diseases.This article summarizes the specific mechanisms of SIRT1 in alcohol-associated liver disease,metabolic dysfunction-associated steatotic liver disease,viral hepatitis,liver fibrosis,and hepatocellular carcinoma.Additionally,the potential applications of SIRT1-targeted interventions in the treatment of chronic liver diseases are briefly discussed,with the aim of providing deeper insights into its unique regulatory mechanisms and offering a theoretical basis for developing more precise therapeutic strategies.

Key words: silent information regulator 1, alcohol-associated liver disease, metabolic dysfunction-associated steatotic liver disease, liver fibrosis, viral hepatitis, hepatocellular carcinoma

CLC Number:

R575

LI Dingjia, ZHANG Yuting, LIU Liangming. Research Progress on Roles of SIRT1 in Hepatic Diseases[J]. Journal of Medical Molecular Biology, 2026, 23(3): 308-315.

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