Advances on Iron Metabolism of Tumor-Associated Macrophages in Tumor Immunity

doi:10.3870/j.issn.1672-8009.2026.03.012

Abstract

Abstract: Tumor-associated macrophages(TAMs)constitute a critical component of the tumor immune microenvironment and are closely linked to the initiation,progression,and metastasis of tumors.Influenced by the tumor microenvironment,the functional plasticity of TAMs determines their diverse roles in tumor immunity.This review summarizes macrophage iron metabolism and its role in tumor immunity,providing insights into the prospects and specific regulatory mechanisms of macrophage-targeted therapy.

Key words: tumor-associated macrophages, iron metabolism, macrophage polarization, PD-1/PD-L1

CLC Number:

DING Jiawen, CHENG Qinpei, LV Tangfeng. Advances on Iron Metabolism of Tumor-Associated Macrophages in Tumor Immunity[J]. Journal of Medical Molecular Biology, 2026, 23(3): 325-330.

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