Abstract: Objective To explore the effect and mechanism of phillyrin on streptozotocin induced diabetic mouse model. Methods  A diabetic mouse Model was established and mice wererandomly divided into 6 groups: Control group, Model group, phillyrin low-dose group, phillyrin medium-dose group, phillyrin high-dose group, and metformin group. The blood glucose value was measured by a glucose meter. The glycosylated hemoglobin detector was used to detect glycosylated hemoglobin. The levels of serum urea nitrogen, creatinine, 24 h urine protein, and the levels of TC, TG, LDL-C, HDL-C, MDA, SOD and GSH-Px were detected by kits. The levels of TNF-α,IL-6, and IL-1β were detected by ELISA. Results Compared with those in the Control group, thelevels of serum urea nitrogen, creatinine and urine protein, the levels of TC, TG, LDL-C, thelevel of MDA content, and the levels of TNF-α, IL-6 and IL-1β were increased in the Modelgroup, while the level of HDL-C, and the levels of SOD and GSH-Px contents were decreased(P < 0. 05). Compared with those in the Model group, the levels of serum urea nitrogen, creatinineand urinary protein, the levels of TC, TG and LDL-C, the level of MDA content, and the levels of TNF-α, IL-6 and IL-1β were decreased in the phillyrin medium and high dose groups and metformin groups, while the level of HDL-C, and the levels of SOD and GSH-Px contents were increased.(P < 0. 05). Conclusion Phillyrin can protect streptozotocin-induced diabetic mice by regulation ofdyslipidemia, oxidative stress, and inflammation.

Key words: diabetes mellitus, phillyrin, inflammation, oxidative stress, dyslipidemia