Abstract: Objective To explore the effect of oridonin on myocardial ischemia-reperfusion injury. Methods A total of 108 rats were randomly divided into 6 groups: sham operation group, I /R group, low-dose, middle-dose and high-dose oridonin treatment groups (2. 5, 5 and 10 mg / kg, continuous intervention for 7 days before surgery) and positive control group (intravenous injection of alprostadil after modeling), with 18 rats in each group. The hemodynamic indicators, myocardial pathological injury, serum oxidative stress indicators, endoplasmic reticulum stress and apoptosisrelated mRNA and protein expression levels and the apoptosis of myocardial cells were detected. Results The oxidative stress indicator and hemodynamics were significantly improved in thehigh-dose oridonin treatment group and positive control group when compared with those in the I / Rgroup, and the myocardial infarction range and myocardial cell apoptosis rate were decreased (P <0. 05). The mRNA expression levels of endoplasmic reticulum stress-related genes were down-regulated (P < 0. 05), and the expression levels of apoptosis-related proteins were declined (P < 0. 05). Conclusion Oridonin can alleviate the myocardial injury in I / R rats, which may be related to alleviating oxidative stress injury and attenuating endoplasmic reticulum stress-induced apoptosis.

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